Active Recombinant Human PDCD1 Protein, Fc-tagged
Cat.No. : | PDCD1-191H |
Product Overview : | Recombinant Human PDCD1 Protein extracellular domain 21-167aa (signal peptide removed), fused with a C-terminal Fc tag, was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. |
Source : | CHO |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Pro 21 |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized human PD-1 at 10 μg/ml (100 μl/well) can bind recombinant human B7-H1 / PD-L1 / Fc chimera with a linear range of 0.02-0.4 μg/ml. |
Molecular Mass : | The recombinant human PDCD1 consists of 379 amino acids and predicts a molecular mass of 42 kDa. |
Endotoxin : | <1.0EU/ug, LAL method |
Purity : | >95% (SDS-PAGE) |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | PDCD1 programmed cell death 1 [ Homo sapiens ] |
Official Symbol : | PDCD1 |
Synonyms : | PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l; |
Gene ID : | 5133 |
mRNA Refseq : | NM_005018 |
Protein Refseq : | NP_005009 |
MIM : | 600244 |
UniProt ID : | Q15116 |
Chromosome Location : | 2q37.3 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem; |
Function : | protein binding; protein tyrosine phosphatase activity; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
PDCD1-692C | Recombinant Cynomolgus monkey PDCD1 Protein | +Inquiry |
PDCD1-700M | Recombinant Mouse PDCD1 Protein, IgG2a Fc-tagged | +Inquiry |
PDCD1-696H | Recombinant Human PDCD1 Protein, Strep-tagged | +Inquiry |
Pdcd1-823MB | Active BiotinylatedRecombinant Mouse Pdcd1 protein(Met1-Gln167), His-tagged | +Inquiry |
PDCD1-22H | Active Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor® 647 conjugated | +Inquiry |
◆ Lysates | ||
PDCD1-2628MCL | Recombinant Mouse PDCD1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (14)
Ask a questionPDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.
PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.
PDCD1 helps develop immune tolerance, preventing overactive immune responses.
PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.
PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.
PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.
PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.
PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.
PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.
PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.
PDCD1 helps develop immune tolerance, preventing overactive immune responses.
Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.
PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.
Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.
Customer Reviews (3)
Write a reviewTimely antibody validation, a valuable asset for our laboratory.
Precise protein quantification, fundamental for maintaining data accuracy.
Dependable peptide synthesis, accelerates our peptide-based projects effectively.
Ask a Question for All PDCD1 Products
Required fields are marked with *
My Review for All PDCD1 Products
Required fields are marked with *
Inquiry Basket