Active Recombinant Human PIK3C2G protein, GST-tagged
Cat.No. : | PIK3C2G-165H |
Product Overview : | Recombinant Human PIK3C2G(468-1203 aa) fused with an N-terminal GST tag was expressed in Insect cells. |
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Description : | PIK3C2G belongs to the phosphoinositide 3-kinase (PI3K) family which plays main roles in signaling pathways and involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2G contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs which mediate translocation of proteins to membranes, and may also mediate protein-protein interactions and the N-terminal region of PIK3C2G and the C-terminal C2 domain are required for enzymatic activity. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 4400 nmol/min/mg |
Molecular Mass : | 110 kDa |
Purity : | >80% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Protein length : | 468-1203 |
Gene Name : | PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide [ Homo sapiens ] |
Official Symbol : | PIK3C2G |
Synonyms : | PIK3C2G; phosphoinositide-3-kinase, class 2, gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2-gamma; PTDINS-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma; phosphoinositide 3-kinase-C2-gamma; phosphatidylinositol 3-kinase C2 domain-containing gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; PI3K-C2GAMMA; MGC163149; |
Gene ID : | 5288 |
mRNA Refseq : | NM_004570 |
Protein Refseq : | NP_004561 |
MIM : | 609001 |
UniProt ID : | O75747 |
Chromosome Location : | 12p12 |
Pathway : | 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Insulin Signaling, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Phosphatidylinositol signaling system, organism-specific biosystem; |
Function : | 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; binding; nucleotide binding; phosphatidylinositol binding; phosphatidylinositol phosphate kinase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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