Active Recombinant Human VCAM1, HIgG1 Fc-tagged

Cat.No. : VCAM1-1794M
Product Overview : The extracellular domain of human VCAM-1 (NP_001069.1) (Lys26-Glu698) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
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Description : This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.
Molecular Mass : 100KDa (monomer)
AA Sequence : Lys26-Glu698
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : VCAM1 vascular cell adhesion molecule 1 [ Homo sapiens ]
Official Symbol : VCAM1
Synonyms : VCAM1; vascular cell adhesion molecule 1; vascular cell adhesion protein 1; CD106; CD106 antigen; INCAM-100; MGC99561; DKFZp779G2333;
Gene ID : 7412
mRNA Refseq : NM_001078
Protein Refseq : NP_001069
MIM : 192225
UniProt ID : P19320
Chromosome Location : 1p32-p31
Pathway : Adaptive Immune System, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
Function : cell adhesion molecule binding; cell adhesion molecule binding; integrin binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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