| Species : |
Human |
| Source : |
E.coli |
| Tag : |
Non |
| Protein Length : |
62-478 aa |
| Description : |
Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
| Form : |
Supplied as 0.2 μm filtered solution in PBS, 0.15 M Arginine, 0.5 mM EDTA, 250 mM N-Acetyl-L-cysteine, pH7.4 with glycerol as protectant. |
| Specificity : |
Host Cell Protein: <0.5 ng/μg of protein tested by ELISA.
Host Cell DNA: <0.02 ng/μg of protein tested by qPCR.
Sterility: Negative
Mycoplasma: Negative |
| Bio-activity : |
Human Vitronectin, premium grade supported the adhesion of iPSC. The typical EC50 for this effect is 1414 ng/mL. |
| Molecular Mass : |
The protein has a calculated MW of 47.6 kDa. The protein migrates as 46 kDa±3 kDa and 53 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE). |
| Endotoxin : |
Less than 0.01 EU/μg by the LAL method/rFC method. |
| Purity : |
>95% as determined by SDS-PAGE. |
| Storage : |
This product is stable after storage at: The product MUST be stored at -70 centigrade or lower upon receipt; -70 centigrade for 3 years under sterile conditions. Please avoid repeated freeze-thaw cycles. |
| Concentration : |
0.2 mg/mL |
| Shipping : |
This product is supplied and shipped with dry ice, please inquire the shipping cost. |
