Active Recombinant Human WNK1 Protein, His tagged

• Cat.No.: WNK1-33H
• Product Overview: This WNK1 recombinant human protein (171-529) was expressed in insect cells.

Specification

• Species: Human
• Source: Insect cells
• Tag: His
• Protein Length: 171-529 aa
• Description: WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
• Form: Liquid, 50mM HEPES, pH 7.5, with 5mM DTT, 20% glycerol, 100mM NaCl
• Molecular Mass: 47 kDa
• Storage: At -80 centigrade, Avoid Freeze/Thaw Cycles
• Shipping: Dry ice

Gene Information

• Gene Name: WNK1 WNK lysine deficient protein kinase 1 [ Homo sapiens (human) ]
• Official Symbol: WNK1
• Synonyms: WNK1; WNK lysine deficient protein kinase 1; hereditary sensory neuropathy, type II, HSN2, PRKWNK1, protein kinase, lysine deficient 1; serine/threonine-protein kinase WNK1; HSAN2; erythrocyte 65 kDa protein; protein kinase with no lysine 1; prostate-derived sterile 20-like kinase; WNK lysine deficient protein kinase 1 isoform; KDP; PSK; p65; HSN2; PRKWNK1; KIAA0344; MGC163339; MGC163341
• Gene ID: 65125
• Protein Refseq: NP_061852
• MIM: 605232
• UniProt ID: Q9H4A3