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Active Recombinant Mouse FLT3 protein, hFc-tagged

Cat.No. : FLT3-1234M
Product Overview : Recombinant Mouse FLT-3/FLK-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn28-Ser544) of mouse FLT-3/FLK-2 (Accession #NP_034359.2) fused with a hFc tag at the C-terminus.
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Source : HEK293
Species : Mouse
Tag : Fc
Form : Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Bio-activity : Mouse FLT3 Ligand, hFc Tag immobilized on CM5 Chip can bind Mouse FLT3, hFc Tag with an affinity constant of 35.07 nM as determined in SPR assay (Biacore T200).
Protein length : Asn28-Ser544
Endotoxin : <1EU/ug
Purity : > 95% as determined by HPLC
Storage : Store the lyophilized protein at -20°C to -80°C for 12 months.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Reconstitution : Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Gene Name : Flt3 FMS-like tyrosine kinase 3 [ Mus musculus ]
Official Symbol : FLT3
Synonyms : FLT3; FMS-like tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; fetal liver kinase 2; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04; MGC124377; MGC124378;
Gene ID : 14255
mRNA Refseq : NM_010229
Protein Refseq : NP_034359

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

        Q&As (7)

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        How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

        FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

        In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

        FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

        How does FLT3 contribute to hematopoiesis? 03/15/2021

        It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

        Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

        Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

        What is the primary biological function of FLT3 in cells? 06/27/2020

        FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

        What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

        It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

        What are the common mutations found in FLT3 associated with diseases? 04/05/2019

        Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

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