Active Recombinant Mouse Ifng Protein (134 aa)
| Cat.No. : | Ifng-379I |
| Product Overview : | Recombinant mouse IFN gamma (rmIFN-γ) produced in E. coli is a non-glycosylated polypeptide chain of 134 amino acids. A fully biologically active molecule, rmIFN--γ has a molecular mass of 15 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques. |
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| Species : | Mouse |
| Source : | E.coli |
| Protein Length : | 134 |
| Description : | Sharing 41% sequence identity with human Interferon gamma (hIFN--γ), mouse IFN gamma (mIFN--γ)is a macrophage-activating factor.The active form of IFN--γ is an antiparallel dimer that sets off IFN--γ/JAK/STAT pathway. IFN--γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity.While IFN--γ–induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN--γ is also implicated in resistance to NK cell and CTL responses and in immune escape in avariety of cancers. |
| Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : | ED50< 0.15 ng/mL, measured by cytotoxicity assay using WEHI-279 cells. |
| Molecular Mass : | 15 kDa, observed by reducing SDS-PAGE. |
| AA Sequence : | MHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQLLPESSLRKRKRSRC |
| Endotoxin : | < 1 EU/μg, determined by LAL method. |
| Purity : | > 95% as analyzed by reducing SDS-PAGE. |
| Storage : | Lyophilized recombinant mouse IFN gamma (rmIFN-γ) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rmIFN-γ should be stable up to 1week at 4 centigrade or up to 2 months at -20 centigrade. |
| Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
| Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
| Gene Name | Ifng interferon gamma [ Mus musculus ] |
| Official Symbol | Ifng |
| Synonyms | IFNG; interferon gamma; IFN-gamma; gamma interferon; Ifg; IFN-g; |
| Gene ID | 15978 |
| mRNA Refseq | NM_008337 |
| Protein Refseq | NP_032363 |
| UniProt ID | P01580 |
Not For Human Consumption!
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