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Active Recombinant Mouse Interleukin 12b

Cat.No. : Il12b-643M
Product Overview : RecombinantMouse Il12b protein was expressed in Spodopterafrugiperda. Met23-Ser335.
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Cat. No. : Il12b-643M
Description : Il12b is apleiotropic cytokine originally identified in the medium of activated human Blymphoblastoid cell lines. Il12b has multiple effectson T cells and NK cells and is a key mediator in the development of Th1cells. Il12b is aheterodimeric cytokine containing two disulfidelinked subunits, p35 and p40.
Source : Spodopterafrugiperda,Sf 21 (baculovirus)-derived.
Form : Lyophilizedfrom a 0.2 um filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence : Met23
MolecularWeight : 35.8 kDa (monomer)
Activity : Measuredby its ability to inhibit the Il12b dependentproliferation of mouse splenocytes activated with PHA and IL-2. The ED50 forthis effect is typically 1-3 ng/mL in the presence of 0.3 ng/mL of mouse Il12b.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 10μg/mL in sterile PBS containing at least 0.1% human or bovine serumalbumin.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Il12b interleukin 12b [ Musmusculus ]
Official Symbol : Il12b
Synonyms : Il12b; interleukin12b; p40;Il-12b; Il12p40; Il-12p40; interleukin-12 subunit beta; CLMF p40; IL-12subunit p40; IL-23 subunit p40; cytotoxic lymphocyte maturation factor 40 kDasubunit
Gene ID : 16160
mRNA Refseq : NM_008352
Protein Refseq : NP_032378
UniProt ID : P43432
Chromosome Location : 11
Pathway : Africantrypanosomiasis; Allograft rejection; Amoebiasis; Cytokine-cytokine receptorinteraction; Herpes simplex infection; Influenza A; Jak-STAT signalingpathway; Legionellosis; Leishmaniasis; Measles; Pertussis; RIG-I-likereceptor signaling pathway; Toll-like receptor signaling pathway; Toxoplasmosis;Type I diabetes mellitus
Function : contributes_tocytokine activity; cytokine receptor activity; contributes_to cytokinereceptor binding; identical protein binding; interleukin-12 alpha subunitbinding; protein binding; protein heterodimerization activity

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