Active Recombinant Mouse Interleukin 27
|Product Overview :||Recombinant mouse p28 is a single-chain 207 amino acid peptide with a mass of approximately 23,697 Daltons.|
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|Cat. No. :||Il27-506M|
|Description :||Recombinant Mouse IL-27/p28 Subunit, also known as Interleukin-30, is a member of the IL-12 family of cytokines. When combined with EBI3 (Epstein-Barr virus induced gene 3), the heterodimer formed is IL-27. Mouse p28is a proinflammatory cytokine inducing immunomodulatory effects. Current research is underway to delineate specific biological functions.|
|Form :||Lyophilized at a concentration of 1 mg/ml in 10mM NaP, 7.5|
|Purity :||Purity ~ 97% as determined by: Reducing and non-reducing SDS-PAGE.|
|Bio-activity :||Mouse p28 biological activity was measured via dose-dependent inhibition of TGF-beta & IL-6-induced IL-17A expression in mouse CD4 splenocytes. 50ng/ml of mouse p28 is capable of inhibiting >25% of IL-17A expression in this assay.|
|Physical Appearance :||Sterile Filtered white lyophilized (freeze-dried) powder.|
|Solubility :||Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 - 0.5 mg"s/ml, which can be further diluted into other aqueous solutions.|
|Purity ~ 97% as determined by :||Reducing and non-reducing SDS-PAGE.|
|Protein Content determined by :||UV spectroscopy at 280 nm. Quantitation on SDS-PAGE against a known standard.|
|Endotoxin Level :||Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.|
|Amino acid sequence :||MFPTDPLSLQ ELRREFTVSL YLARKLLSEV QGYVHSFAES RLPGVNLDLL PLGYHLPNVS LTFQAWHHLSDSERLCFLAT TLRPFPAMLG GLGTQGTWTS SEREQLWAMR LDLRDLHRHL RFQVLAAGFK CSKEEEDKEEEEEEEEEEKK LPLGALGGPN QVSSQVSWPQ LLYTYQLLHS LELVLSRAVR DLLLLSLPRR PGSAWDS|
|Storage :||Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.|
|Gene Name :||Il27 interleukin 27 [ Mus musculus ]|
|Official Symbol :||Il27|
|Synonyms :||Il27; interleukin 27; p28; Il30; IL-27; IL-27p28; interleukin 30; IL-27 p28 subunit|
|Gene ID :||246779|
|mRNA Refseq :||NM_145636|
|Protein Refseq :||NP_663611|
|UniProt ID :||Q8K3I6|
|Chromosome Location :||7 F3|
|Function :||cytokine activity; interleukin-27 receptor binding; protein binding; receptor binding|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.
The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.
The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.
Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.
Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.
Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.
Customer Reviews (3)Write a review
The regulation effect of IL-27 on specific gene expression was detected by Western blot or Real-time PCR. -
IL-27 is a complex cytokine whose function and regulatory mechanisms are still under investigation. -
Immunohistochemistry, immunofluorescence and other techniques can be used to detect the expression and localization of IL-27 in tissues to further understand its function and regulatory mechanism. -
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