Active Recombinant Mouse Mmp9 Protein (20-730aa), C-His-tagged
Cat.No. : | Mmp9-03M |
Product Overview : | Recombinant mouse MMP-9 protein (20-730aa), fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
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Description : | This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Liquid |
Bio-activity : | > 1,500 pmol/min/μg, and is defined as the amount of enzyme that cleaves 1 pmol of Mca-PLGL-Dpa-AR-NH2 per minute at pH 7.5 at 25 centigrade. |
Molecular Mass : | 79.3 kDa (717aa) |
Protein length : | 20-730aa |
AA Sequence : | APYQRQPTFVVFPKDLKTSNLTDTQ LAEAYLYRYGYTRAAQMMGEKQSLR PALLMLQKQLSLPQTGELDSQTLKA IRTPRCGVPDVGRFQTFKGLKWDHH NITYWIQNYSEDLPRDMIDDAFARA FAVWGEVAPLTFTRVYGPEADIVIQ FGVAEHGDGYPFDGKDGLLAHAFPP GAGVQGDAHFDDDELWSLGKGVVIP TYYGNSNGAPCHFPFTFEGRSYSAC TTDGRNDGTPWCSTTADYDKDGKFG FCPSERLYTEHGNGEGKPCVFPFIF EGRSYSACTTKGRSDGYRWCATTAN YDQDKLYGFCPTRVDATVVGGNSAG ELCVFPFVFLGKQYSSCTSDGRRDG RLWCATTSNFDTDKKWGFCPDQGYS LFLVAAHEFGHALGLDHSSVPEALM YPLYSYLEGFPLNKDDIDGIQYLYG RGSKPDPRPPATTTTEPQPTAPPTM CPTIPPTAYPTVGPTVGPTGAPSPG PTSSPSPGPTGAPSPGPTAPPTAGS SEASTESLSPADNPCNVDVFDAIAE IQGALHFFKDGWYWKFLNHRGSPLQ GPFLTARTWPALPATLDSAFEDPQT KRVFFFSGRQMWVYTGKTVLGPRSL DKLGLGPEVTHVSGLLPRRLGKALL FSKGRVWRFDLKSQKVDPQSVIRVD KEFSGVPWNSHDIFQYQDKAYFCHG KFFWRVSFQNEVNKVDHEVNQVDDV GYVTYDLLQCP |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Enzyme Activity |
Notes : | For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/mL (determined by Bradford assay) |
Storage Buffer : | Liquid in. 20mM Tris-HCl (pH 7.5) containing 1mM CaCl2, 100mM NaCl, 10% glycerol |
Gene Name : | Mmp9 matrix metallopeptidase 9 [ Mus musculus (house mouse) ] |
Official Symbol : | Mmp9 |
Synonyms : | MMP9; matrix metallopeptidase 9; matrix metalloproteinase-9; GELB; Gel B; gelatinase B; 92kD gelatinase; 92kDa gelatinase; 92 kDa gelatinase; collagenase type IVB; 92kD type IV collagenase; 92kDa type IV collagenase; 92 kDa type IV collagenase; matrix metalloproteinase 9; Clg4b; MMP-9; B/MMP9; AW743869; pro-MMP-9; |
Gene ID : | 17395 |
mRNA Refseq : | NM_013599 |
Protein Refseq : | NP_038627 |
UniProt ID : | P41245 |
Products Types
◆ Recombinant Protein | ||
MMP9-241H | Recombinant Active Human MMP9 (Q279R) Protein, His-tagged(C-ter) | +Inquiry |
MMP9-5438H | Recombinant Human MMP9 Protein, GST-tagged | +Inquiry |
MMP9-1129H | Recombinant Human MMP9 Protein, His-tagged | +Inquiry |
MMP9-005H | Active Recombinant Human MMP9 Q279R Protein, His-tagged | +Inquiry |
Mmp9-242M | Recombinant Mouse MMP9 Protein, His-tagged(C-ter) | +Inquiry |
◆ Native Protein | ||
MMP9-39H | Native Human MMP-9/Lipocalin Complex | +Inquiry |
MMP9-41H | Native Human MMP-9/TIMP-1 Complex | +Inquiry |
MMP9-40H | Native Human MMP-9/Lipocalin/TIMP-1 Complex | +Inquiry |
◆ Lysates | ||
MMP9-2026MCL | Recombinant Mouse MMP9 cell lysate | +Inquiry |
MMP9-2560HCL | Recombinant Human MMP9 cell lysate | +Inquiry |
MMP9-1940RCL | Recombinant Rat MMP9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-3100 | MMP-9 Fluorimetric Assay Kit | +Inquiry |
Kit-2130 | MMP-9 Inhibitor Screening Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.
Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.
Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.
Q&As (5)
Ask a questionDysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.
Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.
MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.
MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.
MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.
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