Active Recombinant Mouse Ror1 Protein (Gln30-Glu403), C-mFc-tagged

• Cat.No.: Ror1-01M
• Product Overview: Mouse ROR1 (Gln30-Glu403) with a Mouse IgG2a (Glu98-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.

Specification

• Description: This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants.
• Source: Mouse myeloma cell line
• Species: Mouse
• Tag: mFc
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its binding ability in a functional ELISA. Recombinant Mouse ROR1 Fc Chimera binds Biotinylated Recombinant Human/Mouse Wnt-5a with and ED50 of 10-60 μg/mL.
• Molecular Mass: Predicted Molecular Mass: 69 kDa
  SDS-PAGE: 88-100 kDa, reducing conditions
• N-terminal Sequence Analysis: No results obtained. Gln30 inferred from enzymatic pyroglutamate treatment revealing Glu31.
• Endotoxin: < 0.10 EU/μg of the protein by the LAL method.
• Purity: > 95% by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: 12 months from date of receipt, ≤ -20 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
• Reconstitution: Reconstitute at 500 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: Ror1 receptor tyrosine kinase-like orphan receptor 1 [ Mus musculus (house mouse) ]
• Official Symbol: Ror1
• Synonyms: Ror1; receptor tyrosine kinase-like orphan receptor 1; Ntrkr1; 2810404D04Rik; inactive tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1; tyrosine-protein kinase transmembrane receptor ROR1; EC 2.7.10.1
• Gene ID: 26563
• mRNA Refseq: NM_013845
• Protein Refseq: NP_038873
• UniProt ID: Q9Z139

Reviews

10/18/2022

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

08/13/2022

Excellent after-sales service, solving many experimental problems.

04/12/2021

Fast and timely shipment helped me to get satisfactory experimental results in short time.

Q&As

What is the expression level of ROR1 in normal tissues.

ROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.

What are the effects of inhibiting ROR1 expression?

Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.

What biological processes is ROR1 involved in?

ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.

What diseases is ROR1 involved in?

ROR1 is involved in the study of breast, lung and ovarian cancers.