Active Recombinant Mouse TIGIT Homodimer Protein, Fc tagged

• Cat.No.: Tigit-59M
• Product Overview: TIGIT protein dimer contains a TIGIT extracellular domain (UniProt# P86176) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Mouse
• Source: HEK293T
• Tag: Fc
• Protein Length: 29-148 aa
• Description: TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is also known as VSIG9 (V-set and immunoglobulin domain-containing protein 9) and VSTM3 (V-set and transmembrane domain-containing protein 3). TIGIT is a Type I membrane protein containing an immunoglobulin variable (Ig-V) domain, a transmembrane domain and cytoplasmic domain. TIGIT is an immune receptor present on peripheral memory and regulatory CD4+ T cells and natural killer (NK) cells. TIGIT is a pivotal immune checkpoint receptor that fine-tunes T-cell and NK-cell responses. Its dual role in promoting tolerance (via Tregs) and suppressing antitumor immunity makes it a compelling therapeutic target. TIGIT binds to CD155 (the poliovirus receptor, PVR) with high affinity and binds to CD112 (PVRL2) with lower affinity. Nectin-4 is also a ligand for TIGIT. While structurally and functionally similar to human TIGIT, mouse TIGIT is a species-specific tool essential for translational research in cancer immunotherapy.
• Molecular Mass: 79 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for TIGIT and CD155 ligand protein binding assays. SPR for TIGIT and CD155 ligand protein binding assays. Suggested Applications: BLI for TIGIT and Nectin-4 or CD155 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: Tigit T cell immunoreceptor with Ig and ITIM domains [ Mus musculus (house mouse) ]
• Official Symbol: Tigit
• Synonyms: TIGIT; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; Vstm3; ENSMUSG00000071552
• Gene ID: 100043314
• mRNA Refseq: NM_001146325
• Protein Refseq: NP_001139797
• UniProt ID: P86176