Active Recombinant Rat Csf1r protein, His-tagged

Cat.No. : Csf1r-54R
Product Overview : Recombinant Rat Csf1r protein(D4ACA7)(Met1-Glu510), fused with His tag, was expressed in HEK293.
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Source : HEK293
Species : Rat
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Bio-activity : Immobilized rat CSF1R-His at 10 μg/ml (100 μl/well) can bind biotinylated human CSF1-His, The EC50 of biotinylated human CSF1-His is 7.8-18.3 ng/ml.
Molecular Mass : The recombinant rat CSF1R comprises 502 amino acids and predicts a molecular mass of 56.5 kDa. The apparent molecular mass of the recombinant protein is approximately 69-89 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Protein Length : Met1-Glu510
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Csf1r colony stimulating factor 1 receptor [ Rattus norvegicus ]
Official Symbol : Csf1r
Synonyms : CSF1R; colony stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; fms proto-oncogene; proto-oncogene fms; proto-oncogene c-Fms; c-fms; CSF-1R; CSF-1-R; M-CSF-R; MGC125014;
Gene ID : 307403
mRNA Refseq : NM_001029901
Protein Refseq : NP_001025072

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any FDA-approved drugs targeting CSF1R for clinical use? 07/20/2021

Yes, drugs like pexidartinib have been approved for the treatment of certain rare tumors called tenosynovial giant cell tumors (TGCT) that overexpress CSF1R.

How can CSF1R inhibitors impact the tumor microenvironment? 10/22/2018

CSF1R inhibitors can modulate the tumor microenvironment by reducing the number of tumor-associated macrophages and promoting an anti-tumor immune response.

Can CSF1R inhibitors be used in combination with other cancer treatments? 09/20/2018

Yes, CSF1R inhibitors are often used in combination with chemotherapy and immunotherapy to enhance treatment effectiveness.

What are the potential clinical applications of CSF1R inhibitors? 01/21/2017

CSF1R inhibitors are being investigated for cancer therapy to block tumor-promoting macrophages and slow down cancer progression.

Can CSF1R inhibitors be used to treat neurodegenerative diseases? 12/04/2016

Research is ongoing, and CSF1R inhibitors are being explored as a potential therapy for neurodegenerative diseases, but no FDA-approved treatments currently exist.

Customer Reviews (3)

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Reviews
01/09/2022

    With its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.

    10/30/2017

      This variety allows me to select the most appropriate option based on the specific requirements of my research.

      03/10/2017

        the manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the CSF1R protein, which is essential for obtaining accurate and consistent results.

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