Active Recombinant Rhesus macaque CD117 Protein, His&Avi tagged

• Cat.No.: KIT-64R
• Product Overview: CD117 protein dimer contains a CD117 extracellular domain (UniProt# F6V858) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Rhesus macaque
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 25-524 aa
• Description: Cluster of differentiation 117 (CD117), is a member of the type III receptor tyrosine kinase family. CD117 is also known as KIT, C-Kit, mast/stem cell growth factor receptor (SCFR), KIT proto-oncogene receptor tyrosine kinase, and MASTC. CD117 contains an extracellular domain with five immunoglobulin-like loops, a transmembrane domain, a juxtamembrane domain, and an intracellular domain. CD117 is a Type 1 transmembrane protein, expressed on hematopoietic stem cells, mast cells, melanocytes, germ cells, and interstitial cells of Cajal. CD117 exists as a monomer under normal physical conditions. Upon binding to its natural ligand, stem cell factor (SCF), homodimerization occurs between two CD117 monomers; this homodimerization is essential for its activation. However, oncogenic mutations can cause ligand-independent pathological dimerization and constitutive activation. CD117 is frequently overexpressed or dysregulated in human cancers, including gastrointestinal stromal tumors, acute myeloid leukemia, melanoma, and small cell lung cancer. CD117 is a promising drug target, especially in precision oncology and regenerative medicine. The CD117 protein is highly homologous between non-human primates (NHPs) and humans. Understanding CD117 dimerization and its activation is crucial for developing targeted therapeutics.
• Molecular Mass: 132 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for CD117-specific antibody and stem cell factor (SCF) ligand protein binding assays. Suggested Applications: SPR & BLI for CD117-specific antibody and SCF protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: KIT KIT proto-oncogene, receptor tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol 2: KIT
• Synonyms 2: KIT; KIT proto-oncogene, receptor tyrosine kinase; mast/stem cell growth factor receptor Kit; Mast/stem cell growth factor receptor; EC 2.7.10.1
• Gene ID 2: 696759
• mRNA Refseq 2: NM_001266095
• Protein Refseq 2: NP_001253024
• UniProt ID 2: F6V858