Active Recombinant Rhesus Macaque TIGIT Homodimer Protein, His tagged

• Cat.No.: TIGIT-61R
• Product Overview: TIGIT protein dimer contains a TIGIT extracellular domain (UniProt# A0A5F8AKQ5) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Rhesus Macaque
• Source: HEK293T
• Tag: His
• Protein Length: 22-142 aa
• Description: TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is also known as VSIG9 (V-set and immunoglobulin domain-containing protein 9) and VSTM3 (V-set and transmembrane domain-containing protein 3). TIGIT is a Type I membrane protein containing an immunoglobulin variable (Ig-V) domain, a transmembrane domain and cytoplasmic domain. TIGIT is an immune receptor present on peripheral memory and regulatory CD4+ T cells and natural killer (NK) cells. TIGIT is a pivotal immune checkpoint receptor that fine-tunes T-cell and NK-cell responses. Its dual role in promoting tolerance (via Tregs) and suppressing anti-tumor immunity makes it a compelling therapeutic target. TIGIT binds to CD155 (the poliovirus receptor, PVR) with high affinity and binds to CD112 (PVRL2) with lower affinity. Nectin-4 is also a ligand for TIGIT. While structurally and functionally similar to human TIGIT, Rhesus macaque TIGIT is a species-specific tool essential for translational research in cancer immunotherapy.
• Molecular Mass: 43 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for TIGIT-specific antibody binding assays. SPR for TIGIT and PVR ligand protein binding assays. Suggested Applications: BLI and ELISA for TIGIT and PVR protein binding assays and BLI for TIGIT-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: TIGIT T cell immunoreceptor with Ig and ITIM domains [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: TIGIT
• Synonyms: TIGIT; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domain protein
• Gene ID: 710941
• mRNA Refseq: XM_015129816
• Protein Refseq: XP_014985302
• UniProt ID: A0A5F8AKQ5