Cathepsin S Inhibitor Screening Kit (Fluorometric)
Cat.No. : | Kit-2353 |
Product Overview : | Cathepsin S (CTSS, EC 3.4.22.27) is a lysosomal cysteine proteinase that is suggested to participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Cathepsin S Inhibitor Screening Kit utilizes the ability of Cathepsin S to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin S inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This high-throughput adaptable assay kit is simple, sensitive, and rapid tool to screen the potential inhibitors of Cathepsin S. |
- Specification
- Gene Information
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Applications : | Screen/study/characterize potential inhibitors of Cathepsin S. |
Storage : | -20°C |
Size : | 100 assays |
Products Types
◆ Recombinant Protein | ||
CTSS-2118H | Recombinant Human CTSS Protein, GST-tagged | +Inquiry |
CTSS-1329R | Recombinant Rat CTSS Protein, His (Fc)-Avi-tagged | +Inquiry |
Ctss-1293R | Recombinant Rat Ctss Protein, His-tagged | +Inquiry |
CTSS-2766H | Recombinant Human CTSS protein, His-tagged | +Inquiry |
Ctss-1985M | Recombinant Mouse Ctss protein, His-tagged | +Inquiry |
◆ Native Protein | ||
CTSS-27405TH | Native Human CTSS | +Inquiry |
◆ Lysates | ||
CTSS-1563MCL | Recombinant Mouse CTSS cell lysate | +Inquiry |
CTSS-3021HCL | Recombinant Human CTSS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.
Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.
CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.
The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.
Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.
It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.
Customer Reviews (3)
Write a reviewHigh catalytic efficiency, short time, saving time.
The solubility is very good and can be easily dissolved in various buffers.
Anti-pollution ability is very strong, not easy to be polluted.
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