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Recombinant Human Tumor Necrosis Factor, Alpha-Induced Protein 6, His-tagged

Cat.No. : TNFAIP6-3004H
Product Overview : Recombinant Human TNFAIP6 protein was expressed in E.coli with His-tag at the C-terminus. The molecular weight is 31203 Da(277 aa).
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  • Gene Information
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Cat. No. : TNFAIP6-3004H
Description : Tumor necrosis factor, alpha-induced protein 6 also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) gene. TNFAIP6 is a 30 kDa secreted protein that contains a hyaluronan-binding LINK domain a and thus is a member of the hyaluronan-binding protein family, also called hyaladherins. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable, covalent complex with inter-alpha-inhibitor (IαI), and thus enhance the serine protease inhibitory activity of IαI, which is important in the protease network associated with inflammation. The expression of this gene can be induced by a number of signalling molecules, principally tumor necrosis factor α (TNF-α) and interleukin-1 (IL-1). The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation.
Sequences of amino acids : 21-277 aa
Formulation : 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
Purity : 95%
Gene Name : TNFAIP6 tumor necrosis factor, alpha-induced protein 6 [ Homo sapiens ]
Synonyms : TSG6; TSG-6; tumor necrosis factor-inducible gene 6 protein; TNF alpha-induced protein 6; hyaluronate-binding protein; TNF-stimulated gene 6 protein; tumor necrosis factor-inducible protein 6; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor-stimulated gene-6 protein
Gene ID : 7130
mRNA Refseq : NM_007115
Protein Refseq : NP_009046
MIM : 600410
UniProt ID : P98066
Chromosome Location : 2q23.3
Function : Binding; hyaluronic acid binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TNFAIP6 interact with other proteins in the inflammatory cascade? 01/13/2022

TNFAIP6 interacts with various proteins involved in the inflammatory cascade, exerting its anti-inflammatory effects by modulating cytokines and growth factors.

In what ways does TNFAIP6 influence cell migration? 06/05/2021

TNFAIP6 has been shown to influence cell migration, a critical aspect of tissue repair, by regulating the interactions between cells and the extracellular matrix.

How does TNFAIP6 contribute to tissue repair? 06/09/2020

TNFAIP6 plays a crucial role in tissue repair by modulating the activity of hyaluronic acid, which is involved in tissue regeneration and wound healing.

Are there therapeutic applications of TNFAIP6 in tissue regeneration? 10/30/2019

Studies are exploring the therapeutic potential of TNFAIP6 in promoting tissue regeneration, particularly in the context of joint and cartilage repair.

Can TNFAIP6 be used as a biomarker for inflammatory diseases? 04/18/2017

Research suggests that TNFAIP6 levels may serve as a potential biomarker for certain inflammatory conditions, aiding in diagnosis and monitoring disease progression.

Customer Reviews (3)

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Reviews
08/01/2020

    Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.

    05/18/2016

      Its high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.

      04/11/2016

        With the TNFAIP6 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.

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