"METTL1" Related Products

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Recombinant Human METTL1, His-tagged, 33.6kDa (296aa)

Cat. No.: METTL1-953H
Product Overview: Recombinant human METTL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: METTL1 is known as tRNA (guanine-N (7)-)-methyltransferase which belongs to the methyltransferase superfamily. METTL1 shows high sequence similarity to yeast ORF YDL201w and has been shown to be inactivated by phosphorylation. This protein contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphylation. It catalyzes the formation of N (7)-methylguanine at position 46 (m7G46) in tRNA.
Source: E.coli.
Form: Liquid. In Phosphate Buffered Saline pH7.4 containing 10% glycerol.
Molecular Weight: 33.6kDa (296aa) confirmed by MALDI-TOF.
Purity: > 90% by SDS - PAGE.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAAETRNVAG AEAPPPQKRY YRQRAHSNPM ADHTLRYPVK PEEMDWSELY PEFFAPLTQN QSHDDPKDKK EKRAQAQVEF ADIGCGYGGL LVELSPLFPD TLILGLEIRV KVSDYVQDRI RALRAAPAGG FQNIACLRSN AMKHLPNFFY KGQLTKMFFL FPDPHFKRTK HKWRIISPTL LAEYAYVLRV GGLVYTITDV LELHDWMCTH FEEHPLFERV PLEDLSEDPV VGHLGTSTEE GKKVLRNGGK NFPAIFRRIQ DPVLQAVTSQ TSLPGH.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: METTL1 methyltransferase like 1 [ Homo sapiens ]
Synonyms: methyltransferase like 1; TRM8; C12orf1; YDL201w; FLJ95748; METT- L1;tRNA (guanine-N(7)-)-methyltransfe rase; D1075-like gene product; methy- ltransferase-like 1; tRNA(m7G4- 6)-met hyltransferase; methyltransfera- se-like protein 1; Methyltransferase-like protein 1
Gene ID: 4234
mRNA Refseq: NM_005371
Protein Refseq: NP_005362
MIM: 604466
UniProt ID: Q9UBP6
Chromosome Location: 12p13
Function: methyltransferase activity; protein binding; tRNA (guanine-N7-)-methyltransferase activity; contributes_to tRNA (guanine-N7-)-methyltransferase activity; tRNA binding; transferase activity

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