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Recombinant Human Lipocalin 2, His-tagged

Cat.No. : LCN2-3409H
Product Overview : Recombinant human LCN2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Cat. No. : LCN2-3409H
Description : Neutrophil gelatinase-associated lipocalin (NGAL), also known as LCN2, belongs to the calycin superfamily and Lipocalin family. LCN2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. The binding of LCN2 to bacterial siderophores is important in the innate immune response to bacterial infection. Also LCN2 functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans.
Source : E.coli.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT, 50mM NaCl.
Molecular Weight : 22.8kDa (199aa) confirmed by MALDI-TOF.
Purity : > 90% by SDS – PAGE.
Concentration : 1mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MQDSTSDLIP APPLSKVPLQ QNFQDNQFQG KW YVVGLAGN AILREDKDPQ KMYATIYELK EDKSYNVTSV LFRKKKCDYW IRTFV PGCQP GEFTLGNIKS YPGLTSYLVR VVSTNYNQHA MVFFKKVSQN REYFKITLYG RTKELTSELK ENFIRFSKSL GLPENHIVFP VPIDQCIDG.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : LCN2 lipocalin 2 [ Homo sapiens ]
Synonyms : LCN2; 25 kDa alpha-2-microglobulin- related subunit of MMP-9;lipocalin 2; 24p3; MSFI; NGAL; HNL; siderocalin; oncogene 24p3; OTTHUMP0000002- 2240; migration-stimulating factor in- hibitor; neutrophil gelatinase-associa- ted lipocalin; lipocalin 2 (oncogene 24p3); Neutrophil gelatinase-associat- ed lipocalin; p25; Lipocalin-2; Oncog- ene 24p3; OTTHUMP00000022238
Gene ID : 3934
mRNA Refseq : NM_005564
Protein Refseq : NP_005555
MIM : 600181
UniProt ID : P80188
Chromosome Location : 9q34
Function : binding; transporter activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What diseases are associated with mutations or abnormal expression of the LCN2 protein? 06/19/2022

Mutations or abnormal expression of the LCN2 protein may be associated with a variety of diseases. For example, in hereditary kidney disease, mutations in the uNGAL gene can lead to kidney damage. In addition, in inflammatory diseases, tumors, and other diseases, the expression level of LCN2 protein may also change.

What diseases are LCN2 protein expression levels associated with? 11/15/2020

Studies have shown that the expression level of LCN2 protein is associated with a variety of diseases. For example, in kidney disease, expression levels of the LCN2 protein can be elevated and can be used as one of the biomarkers to assess the extent of kidney damage. In addition, in inflammatory diseases, tumors, and other diseases, the expression level of LCN2 protein can also change.

What is the interaction between the LCN2 protein and other proteins or molecules? 07/22/2020

The interaction between the LCN2 protein and other proteins or molecules is complex. For example, it can participate in lipid metabolism processes by interacting with lipid molecules. In addition, it can interact with other signal transduction molecules to participate in the signal transduction process.

How can the expression level of LCN2 protein be used for disease diagnosis? 04/03/2020

Kidney function can be assessed by measuring the level of uNGAL in urine, and to help diagnose kidney disease, etc. In addition, abnormal levels of LCN2 protein expression can also be used as an indicator to assess the risk and prognosis of other diseases.

How is the activity of LCN2 protein regulated? 02/16/2020

The activity of the LCN2 protein is regulated by a variety of factors. First, its expression level is regulated by gene expression. Secondly, its activity is also regulated by a variety of small molecule compounds, hormones and other substances. In addition, the LCN2 protein can also regulate its activity by interacting with other proteins.

How does the LCN2 protein relate to other biomarkers? 06/06/2019

LCN2 protein has some association with other biomarkers. For example, in kidney disease, expression levels of uNGAL can be used alongside traditional biomarkers such as creatinine to assess kidney function and degree of impairment. In addition, in diseases such as tumors, expression levels of the LCN2 protein may also change and be associated with other biomarkers.

Customer Reviews (3)

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Reviews
05/02/2022

    They have a wide range of products and can always find LCN2 we need.

    03/11/2021

      The reproducibility of LCN2 is almost 100 percent, and the results are very consistent in every experiment or application, which is an important reflection of its excellent quality.

      12/15/2019

        Catalytic activity of LCN2 is really amazing, and every time it is used, it gives an unexpected catalytic effect and its performance is impressive.

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