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Recombinant Human Core-binding Factor, Beta Subunit, His-tagged

Cat. No.: CBFB-2776H
Product Overview: Recombinant human CBFB protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW = 23.6 kDa(202aa).
Description: CBFB, also known as PEBP2B, is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). This protein is a non-DNA binding regulatory subunit and it allosterically enhances DNA binding by alpha subunit.
Source: E.coli.
Form: Liquid. In 20 mM MES (pH 6.0) containing 0.1 mM PMSF, 10% Glycerol.
Purity: > 85% by SDS - PAGE.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MPRVVPDQRS KFENEEFFRK LSRECEIKYT GF RDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFPASWQGEQRQT PSREY VD LE R EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RA QQE DAL AQ QAFEEARRRT REFEDRDRSHREEMEVRVSQ LLAVTGKKTT RP.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: CBFB core-binding factor, beta subunit [ Homo sapiens ]
Synonyms: core-binding factor, beta subunit; Polyomavirus enhancer-binding protein 2 beta subunit; PEBP2B; CBFB; core-binding factor subunit beta; CBF-beta; PEA2-beta; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; polyomavirus enhancer-binding protein 2 beta subunit; polyomavirus enhancer binding protein 2, beta subunit
Gene ID: 865
mRNA Refseq: NM_001755
Protein Refseq: NP_001746
MIM: 121360
UniProt ID: Q13951
Chromosome Location: 16q22.1
Function: RNA polymerase II transcription factor activity; protein binding; transcription coactivator activity; transcription factor activity

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