"DR1" Related Products

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Recombinant Human DR1, His-tagged

Cat. No. : DR1-2777H
Product Overview : Recombinant human DR1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography.MW = 21.6 kDa(196aa).
Description : DR1, also known as NC2-beta, is a TBP (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. By selectively repressing polymerases II and III, DR1 may shift the physiological balance of transcriptional output in favor of polymerase I.
Source : E.coli.
Form : Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 100 mM NaCl, 0.1 mM PMSF ,10% Glycerol.
Purity : > 85% by SDS - PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MASSSGNDDD LTIPRAAINK MIKETLPNVR VAND ARELVV NCCTEFIHLI SSEANEICNK SEKKTISPEHVIQALESLGF GSYISEVKEV LQE CKTVALK RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WL QMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) [ Homo sapiens ]
Synonyms : DR1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2; NC2-BETA; down-regulator of transcription 1; OTTHUMP00000012557; Protein Dr1; TATA-binding protein-associated phosphoprotein; Negative cofactor 2-beta; NC2-beta
Gene ID : 1810
mRNA Refseq : NM_001938
Protein Refseq : NP_001929
MIM : 601482
UniProt ID : Q01658
Chromosome Location : 1p22.1
Function : sequence-specific DNA binding; transcription corepressor activity; transcription factor binding

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