"TSN" Related Products

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Recombinant Human Translin

Cat. No.: TSN-2834H
Product Overview: Recombinant human Translin protein, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 26.1kDa (228aa) confirmed by MALDI-TOF.
Description: Translin, also known TSN, is a DNA and RNA binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin forms a ring-shaped structure, which is responsible for DNA binding, and also contains a leucine zipper motif, which is thought to enable translin to form dimers. Translin exports specific mRNAs out of the nucleus, supported by its localization in both the nuclei and cytoplasm of neurons, and regulates their translation.
Source: E.coli.
Sequences Of Amino Acids: MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGAG FQDIPKRCLK AREHFGTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF LAAFVVYLET ETLVTREAVT EILGIEPDRE KGFHLDVEDY LSGVLILASE LSRLSVNSVT AGDYSRPLHI STFINELDSG FRLLNLKNDS LRKRYDGLKY DVKKVEEVVY DLSIRGFNKE TAAACVEK
Purity: > 90% by SDS – PAGE.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol. 100mM NaCl.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: TSN translin [ Homo sapiens ]
Synonyms: TSN; translin; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1; OTTHUMP00000203715; OTTHUMP00000203716; recombination hotspot-binding protein; recombination hotspot associated factor
Gene ID: 7247
mRNA Refseq: NM_004622
Protein Refseq: NP_004613
MIM: 600575
UniProt ID: Q15631
Chromosome Location: 2q21.1
Function: DNA binding; mRNA binding; protein binding; sequence-specific DNA binding

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