||Recombinant Chicken IL-16 was expressed inYeast. MW= 12.6 kDa (120 aa).
||IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. IL-16 functions exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene. IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. Also induces t-lymphocyte expression of interleukin 2 receptor. ligand for cd4.
||Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
||>95% as visualized by SDS-PAGE analysis.
|Amino Acid Sequence:
||SSTSSVASDA SQESTTEETI CTITLDKTAA GLGFSLEGGK GSIHGDKPII INRIFKGTSL EQSSPVQPGD ELLQVHTTAL QGLTRFEAWN IIKALPDGPI TAIIKRKNPS SVTKKASETL.
||The biological activity of recombinant chicken IL-16 was determined in a chemotaxis assay using a Boyden chamber with chicken PBMC following initial culture with IL-16. Bioactivity is typically detected starting at 78 ng/mL.
|Stability And Storage:
||Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.