Native Human IL16
Cat.No. : | IL16-29736TH |
Product Overview : | Synthetic peptide (Human) |
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Description : | The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. |
Source : | E. coli |
Tissue specificity : | Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation. |
Form : | Lyophilised:Reconstitute with distilled water to achieve desired concentration. |
Storage buffer : | Preservative: NoneConstituents: 5mM Sodium citrate, 0.5mM DTT, pH 5.5 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | Recombinant Human IL-16 is a 13.5 kDa protein containing 130 amino acid residues.:MPDLNSSTDSAASASAASDVSVEST AEATVCTVTLEKMSAGLGFSLEGGK GSLHGDKPLTINRIFKGAASEQSET VQPGDEILQLGGTAMQGLTRFE AWNIIKALPDGPVTIVIRRKSLQSK ETTAAGDS |
Sequence Similarities : | Contains 4 PDZ (DHR) domains. |
Tag : | Non |
Gene Name : | IL16 interleukin 16 [ Homo sapiens ] |
Official Symbol : | IL16 |
Synonyms : | IL16; interleukin 16; interleukin 16 (lymphocyte chemoattractant factor); pro-interleukin-16; FLJ16806; FLJ42735; HsT19289; IL 16; LCF; lymphocyte chemoattractant factor; prIL 16; prointerleukin 16; |
Gene ID : | 3603 |
mRNA Refseq : | NM_001172128 |
Protein Refseq : | NP_001165599 |
MIM : | 603035 |
Uniprot ID : | Q14005 |
Chromosome Location : | 15q26.3 |
Function : | cytokine activity; |
Products Types
◆ Lysates | ||
IL16-5245HCL | Recombinant Human IL16 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewSuitable for ELISA.
High specificity in ELISA.
Potent in chemotaxis studies.
Q&As (10)
Ask a questionLeukocyte migration assays measure IL16's chemotactic impact on cells.
Flow cytometry and qPCR assess T cell activation markers affected by IL16.
Gene expression arrays reveal IL16's influence on inflammatory gene profiles.
RNA interference used to knock down IL16 expression in cell lines.
Experimental setup for studying IL16's modulation of HIV infection involves viral assays.
Binding affinity of IL16 to CD4 receptors determined through SPR or ITC.
Flow cytometry and confocal microscopy visualize IL16's cellular localization.
Mouse models and clinical samples aid in understanding IL16's role in autoimmunity.
ELISA quantifies secreted IL16 levels from cell culture supernatants.
Strategies like animal models and patient samples explore IL16's role in allergies.
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