"JAK2" Related Products

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Recombinant Human Janus Kinase 2, His-tagged

Cat. No. : Jak2-532H
Product Overview : Recombinant human JAK2 was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=42.5kDa.
Description : JAK2 is a member of intracellular non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. JAK2 has two near-identical phosphate-transferring domains. One domain exhibits the kinase activity while the other stabilizes the JAK conformational structure. JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin. JAK2 has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon.
Source : Sf9 insect cells.
Purity : >90%.
Specific Activity : 118 pmol/min/μg, Assay conditions: 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EGTA, 200 μM ATP, 0.01% Brij-35, and 2 μM substrate (Tyr 4, Invitrogen) at room temperature for 1 hour. Developer solution was added to reaction and reaction was stopped after 1h of incubation at RT.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 10% glycerol, and 1 mM DTT.
Stability : >6 months at –80°C.
Gene Name : JAK2 Janus kinase 2 [ Homo apiens ]
Synonyms : JAK2; Janus kinase 2; JTK10; tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase); EC 2.7.10.2; JAK-2; OTTHUMP00000021024; OTTHUMP00000043260
Gene ID : 3717
mRNA Refseq : NM_004972
Protein Refseq : NP_004963
MIM : 147796
UniProt ID : O60674
Chromosome Location : 9p24
Pathway : Adipocytokine signaling pathway; Chemokine signaling pathway; Jak-STAT signaling pathway
Function : ATP binding; Janus kinase activity; SH2 domain binding; acetylcholine receptor binding; growth hormone receptor binding; insulin receptor substrate binding; interleukin-12 receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; peptide hormone receptor binding; phosphoinositide 3-kinase binding; transferase activity

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