Recombinant Human MSH6, GST-tagged

• Cat.No.: MSH6-2412H
• Product Overview: MSH6 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 51 amino acids (350-400 a.a.) having a total Mw of 33 kDa. Human MSH6 is fused to a GST tag and purified by proprietary chromatographic techniques.

Specification

• Description: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Sterile Filtered clear solution. MSH6 is supplied in 50mM Tris-HCl, pH-7.5, 10mM L-glutathione (reduced).
• Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: MSH6 mutS homolog 6 [ Homo sapiens (human) ]
• Official Symbol: MSH6
• Synonyms: MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; mutS homolog 6; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein
• Gene ID: 2956
• mRNA Refseq: NM_000179
• Protein Refseq: NP_000170
• MIM: 600678
• UniProt ID: P52701
• Chromosome Location: 2p16
• Pathway: BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Mismatch repair
• Function: contributes_to ADP binding; contributes_to ATPase activity; contributes_to MutLalpha complex binding