|Cat. No. :
|Product Overview :
||Recombinant human CD4 Fc Chimera (rhCD4-Fc) Lys26-Trp390 fused with Fc fragment Of human IgG1 at the C-terminal,was expressed in human HEK293 cells and purified by using conventional chromatography techniques.
||This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
||>95% as determined by SDS-PAGE. All lots are greater than 90% pure.
|Molecular Weight :
||Bulk protein in a 0.22 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.0 and delivered as liquid formulation or lyophilized powder.Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
|Predicted N-terminal :
||Less than 1.0 EU per 1 μg of the rhCD4-Fc by the LAL method.
||Store at -20℃ in lyophilized state after receipt. For long term storage, upon reconstitution rhCD4-Fc should be aliquot and store at -20°C or -80°C. Avoid repeated freeze-thaw cycles.