Recombinant Human Synaptotagmin I, His-tagged
Cat.No. : | SYT1-5131H |
Product Overview : | Recombinant humanSYT1 protein, fused to His-tag at C-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Cat. No. : | SYT1-5131H |
Description : | SYT1(Synaptotagmin-1) belongs to the synaptotagmin family and contains 2 C2domains. The synaptotagmins are integral membrane proteins of synapticvesicles thought to serve as Ca(2+) sensors in the process ofvesicular trafficking and exocytosis. SYT1 is the master switch responsiblefor allowing the human brain to release neurotransmitters. |
Concentration : | 0.25 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 20% glyceroland 100mM NaCl. |
Purity : | > 85% by SDS -PAGE |
Sequence : | 136-382 amino acids:MEPKEEEKLG KLQYSLDYDF QNNQLLVGII QAAELPALDM GGTSDPYVKV FLLPDKKKKF ETKVHRKTLNPVFNEQFTFK VPYSELGGKT LVMAVYDFDR FSKHDIIGEF KVPMNTVDFG HVTEEWRDLQ SAEKEEQEKLGDICFSLRYV PTAGKLTVVI LEAKNLKKMD VGGLSDPYVK IHLMQNGKRL KKKKTTIKKN TLNPYYNESFSF |
Molecular Mass : | 29.5 kDa(256aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | SYT1 |
Gene Name : | SYT1synaptotagmin I [ Homo sapiens ] |
Synonyms : | SYT1; synaptotagmin I; P65; SYT; SVP65; DKFZp781D2042; synaptotagmin-1sytI; synaptotagmin 1; Synaptotagmin-1; Synaptotagmin I; SytI; OTTHUMP00000166063;OTTHUMP00000166064 |
Gene ID : | 6857 |
mRNA Refseq : | NM_001135805 |
Protein Refseq : | NP_001129277 |
MIM : | 185605 |
UniProt ID : | P21579 |
Chromosome Location : | 12cen-q21 |
Pathway : | AcetylcholineNeurotransmitter Release Cycle; Botulinum neurotoxicity; DopamineNeurotransmitter Release Cycle; Effects of Botulinum toxin; GABA synthesis,release; Glutamate Neurotransmitter Release Cycle; Neurotransmitter ReleaseCycle; Norepinephrine Neurotransmitter Release Cycle; SerotoninNeurotransmitter Release Cycle; Synaptic Transmission; Synaptic vesicle cycle;Translocation of BoNT Light chain; Transmission across Chemical Synapses |
Function : | 1-phosphatidylinositolbinding; calcium ion binding; calcium-dependentprotein binding; calmodulin binding; identical protein binding; low-densitylipoprotein receptor binding; phospholipid binding; protein binding; syntaxin-1 binding; transporter activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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