Recombinant Human PTPRB, GST-tagged


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Recombinant Human PTPRB, GST-tagged

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Cat. No. : PTPRB-1859H
Product Overview : Recombinant human PTPRB protein(1675-1996) with N-terminal GST tag was expressed in anE.coliexpression system, MW= 63.7 kDa.
Description : Receptor-type tyrosine-protein phosphatase beta is an enzyme that in humans is encoded by the PTPRB gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
Source : E.coli.
Formulation : 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
Purity : > 95% by SDS-PAGE.
Specific Activity : 40 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP.
Application : Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
Storage : >6 months at –80°C.
Pathways : Adherens junction
PDB rendering based on 2ahs :

Gene Name : PTPRB protein tyrosine phosphatase, receptor type, B [ Homo sapiens ]
Synonyms : protein tyrosine phosphatase, receptor type, B; PTPB; HPTPB; VEPTP; FLJ44133; MGC59935; HPTP-BETA; MGC142023; R-PTP-BETA; DKFZp686E2262; DKFZp686H15164; PTPRB; receptor-type tyrosine-protein phosphatase beta;VE-PTP; EC; protein-tyrosine phosphatase beta; vascular endothelial protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, beta polypeptide;R-PTP-beta;Protein-tyrosine phosphatase beta
Gene ID : 5787
mRNA Refseq : NM_001109754
Protein Refseq : NP_001103224
MIM : 176882
UniProt ID : P23467
Chromosome Location : 12q15-q21
Function : hydrolase activity; protein binding; transmembrane receptor protein tyrosine phosphatase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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