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Recombinant Human Ret Proto-Oncogene, GST-tagged

Cat. No.: RET-1850H
Product Overview: Recombinant Human Ret (a.a. 658-end) with Nterminal GST tag expressed in anBaculovirus infected Sf9 cellexpression system. MW= 77.5 kDa.
Description: The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules.[1] RET loss of function mutations are associated with the development of Hirschsprung"s disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, phaeochromocytoma and parathyroid hyperplasia.
Source: Baculovirus infected Sf9 cells.
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Specific Activity: 40 U/ug. One unit is defined as the amount of enzyme that will transfer 1 pmol phosphate to Tyr substrate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 uM Na-orthovanadate, 0.1 mM ATP, 30 ug/ml Poly (Glu:Tyr)4:1 substrate, and 2 ug/ml recombinant cMet.
Purity: >80% by SDS-PAGE.
Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 10 mM reduced glutathione, and 3 mM DTT.
Stability: >6 months at -80°C.
Gene Name: RET ret proto-oncogene [ Homo sapiens ]
Synonyms: ret proto-oncogene; PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1; RET; proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherin family member 12; hydroxyaryl-protein kinase; cadherin-related family member 16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); Hirschsprung disease 1; multiple endocrine neoplasia and medullary thyroid carcinoma 1; C-ret;EC 2.7.10.1
Gene ID: 5979
mRNA Refseq: NM_020630.4
Protein Refseq: NP_065681.1
MIM: 164761
UniProt ID: P07949
Chromosome Location: 10q11.2
Pathway: Endocytosis; Pathways in cancer; Thyroid cancer
Function: ATP binding; calcium ion binding; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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