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Recombinant Human Insulin-like Growth Factor 2 (somatomedin A)

Cat.No. : IGF2-609H
Product Overview : Recombinant humanIGF2 protein was expressed in E. coli. They are made by reacting hIGF-II withSulfo-NHS-Biotin reagent. In di-biotinyl-human-IGF-II both the a-amino groupof the N-terminal alanine and the e-amino group of the lysine at position 65are biotinylated.
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Cat. No. : IGF2-609H
Description : IGF2 is one ofthree protein hormones that share structural similarity to insulin. IGF2 iscreated by Theca cells to act in an autocrine manner on the theca cellsthemselves, and in a paracrine manner on Granulosa cells in the ovary. IGF2promotes granulosa cell proliferation during the follicular phase of themenstrual cycle, acting alongside Follicle Stimulating Hormone.
Source : Following thereaction of hIGF-II with Sulfo-NHS-Biotin reagent , the mono- anddi-biotinyl-human-IGF-II are separated from the other reaction products byHPLC. The mono-biotinyl-human-IGF-II and the di-biotinyl-human-IGF-II peaksare then further purified by HPLC to yield Receptor Grade products.
Species : Human
Purity : Greater than 95 %(by HPLC)
Molecular Weight : Mono-biotinyl-human-IGF-II-7696daltons; Di-biotinyl-human-IGF-II-7922 daltons; Homogeneity and mass of bothconfirmed by Mass Spectrometry.
N-terminal sequence analysis : 5 residues Greaterthan 95 % single sequence.
Biological Activity : Western ligand blotto bovine IGFBP-2.
Endotoxin : Less than 0.1 EU/μg
State and appearance : Lyophilized whitepowder. Dried from 0.1 M acetonitrile/ 0.1% trifluoroacetic acid and storedunder dry nitrogen at a slight vacuum (-25 kPa).
Reconstitution : Handling of GroPepIGF-I, IGF-II and IGF Analogs.
Storage : At least 2 years at2 - 4°C (lyophilized).
OfficialSymbol : IGF2
Pathways : Apoptosis; Diabetespathways; Endochondral Ossification; Hedgehog Signaling Pathway; Regulationof Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth FactorBinding Proteins (IGFBPs)
Gene Name : IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ]
Synonyms : IGF2;insulin-like growth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43;FLJ22066; FLJ44734; insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2; chromosome11 open reading frame 43; Insulin-like growth factor II; Somatomedin-A
Gene ID : 3481
mRNA Refseq : NM_001127598
Protein Refseq : NP_001121070
MIM : 147470
UniProt ID : P01344
Chromosome Location : 11p15.5
Function : growth factoractivity; hormone activity; insulin receptor binding; insulin-like growthfactor receptor binding; protein binding; protein serine/threonine kinaseactivator activity; receptor activator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can IGF2 be used as a predictive marker for certain diseases? 11/12/2021

Yes, IGF2 levels may serve as predictive markers for certain diseases. Monitoring its expression could help identify individuals at risk or track disease progression.

How can IGF2 be targeted for therapeutic interventions? 04/20/2021

Researchers are exploring various approaches, including drug development, to modulate IGF2 levels for therapeutic purposes. This may involve targeting its receptors or modifying its expression.

How does IGF2 relate to aging and age-related diseases? 12/28/2020

IGF2 has been linked to the aging process and age-related diseases. Exploring its role may provide insights into slowing down aging or managing age-related conditions.

Are there therapeutic applications of IGF2 in regenerative medicine? 12/08/2020

Research is exploring the potential use of IGF2 in regenerative medicine due to its role in cell growth and tissue repair. It may offer new avenues for tissue regeneration.

Are there clinical trials exploring IGF2 as a therapeutic target? 05/21/2019

Yes, there are ongoing clinical trials investigating the use of IGF2 in various conditions. These trials aim to assess its safety and efficacy in a clinical setting.

Customer Reviews (3)

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01/24/2023

    The IGF2 protein is an exceptional choice that meets the highest standards of quality, making it perfectly suited for your experimental needs.

    01/26/2019

      The IGF2 protein is of the highest quality and perfectly suited for your experimental requirements.

      01/20/2019

        In addition to its exceptional quality, the IGF2 protein is backed by excellent technical support offered by the manufacturer.

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