Recombinant Human Insulin-like Growth Factor Binding Protein 4

• Cat.No.: IGFBP4-614H
• Product Overview: Recombinant humanIGFBP4 protein was expressed in E. coli. IGFBP4 inhibits the activity ofIGF-I and IGF-II by binding in a manner that results in the formation ofcomplexes with reduced ability to signal through cell surface IGF receptors.

Specification

• Cat. No.: IGFBP4-614H
• Description: This gene is amember of the insulin-like growth factor binding protein (IGFBP) family andencodes a protein with an IGFBP domain and a thyroglobulin type-I domain. Theprotein binds both insulin-like growth factors (IGFs) I and II and circulatesin the plasma in both glycosylated and non-glycosylated forms. Binding ofthis protein prolongs the half-life of the IGFs and alters their interactionwith cell surface receptors.
• Source: E. coli
• Species: Human
• Form: Lyophilized from asterile solution without additives.
• Purity: >98.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
• Molecular Weight: 26.1 kDa
• Endotoxin Level: <0.1 ng/μg ofprotein.
• Reconstitution: Centrifuge vialprior to opening. Reconstituted in water to a concentration of 0.1-1.0 mg/ml.This solution can be diluted in water or other buffer solutions or stored at-20°C.
• Storage: The lyophilizedprotein is stable for a few weeks at room temperature, but best stored at -20°C.Reconstituted human IGFBP4 should be stored in working aliquots at -20°C. Avoidrepeated freeze-thaw cycles.
• OfficialSymbol: IGFBP4
• Pathways: Diabetes pathways; MyometrialRelaxation and Contraction Pathways; Regulation of Insulin-like Growth Factor(IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs); Wntsignaling network

Gene Information

• Gene Name: IGFBP4 insulin-like growthfactor binding protein 4 [ Homo sapiens ]
• Synonyms: IGFBP4; insulin-likegrowth factor binding protein 4; BP-4; IBP4; IGFBP-4; HT29-IGFBP; insulin-likegrowth factor-binding protein 4; IBP-4; OTTHUMP00000164451; IGF-bindingprotein 4; Insulin-likegrowth factor-binding protein 4
• Gene ID: 3487
• mRNA Refseq: NM_001552
• Protein Refseq: NP_001543
• MIM: 146733
• UniProt ID: P22692
• Chromosome Location: 17q12-q21.1
• Function: insulin-like growthfactor binding