Native Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 1


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Native Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 1

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Cat. No. : SERPINA1-5358H
Product Overview : Native humanSERPINA1 is a serum glycoprotein synthesized in the liver. Its molecularweight is 51000 Dalton.
Description : SERPINA1 acts as anelastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin,collagenase, leucocytic proteases, plasmin, and thrombin, which may bereleased during inflammatory reactions in the lung. Human SERPINA1 consistsof a single polypeptide chain and exists in a number of genetic variants. Inthe absence of human SERPINA1, these enzymes are not inhibited and they maydigest pulmonary parenchyma. Human API deficiency is associated with chronicobstructive lung disease (emphysema) and less frequently with hepaticcirrhosis in infants and respiratory distress of the newborn. Increase inhuman SERPINA1 occurs as an acute phase response to tissue necrosis andinflammation. Serum level of human SERPINA1 is elevated in rheumatoidarthritis, bacterial infections, vasculitis, and carcinomatosis. Incolorectal and lung carcinomas, human SERPINA1 has also related to theirinvasive and metastatic capacity. The average level of human SERPINA1 inplasma is 1.3 g/L.
Form : Sterile filteredliquid in PBS + 7 mg NaCl
Source : Human plasm
Concentration : 20.0 mg/ml
Molecular Weight : 51.0 kDa
Purity : > 95% asdetermined by RP-HPLC and SDS-PAGE analyses.
Endotoxin Level : < 0.1 ng/µg ofSERPINA1
Biological Activity : 1-4 mg will inhibit1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. 2-6 mgwill inhibit approximately 1.0 mg of a-chymotrypsin with activity of 40-50BTEE units per mg protein.
Storage : Store at 2-4°C. DoNot Freeze.
OfficialSymbol : SERPINA1
Pathways : Complement andCoagulation Cascades; FOXA1 transcription factor network; Hemostasis;Platelet activation, signaling and aggregation; Platelet degranulation;Response to elevated platelet cytosolic Ca2+
Crystal structure of serpin A1 (red) in aninhibitory complex with pancreatic elastase (blue). Rendered from PDB 2D26. :

Gene Name : SERPINA1 serpin peptidase inhibitor, cladeA (alpha-1 antiproteinase, antitrypsin), member 1 [ Homo sapiens ]
Synonyms : SERPINA1; serpinpeptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1;serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,antitrypsin), member 1PI; PI; A1A; AAT; PI1; A1AT; MGC9222; PRO2275;MGC23330; alpha1AT; alpha-1-antitrypsin; protease inhibitor 1 (anti-elastase),alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase;Serpin A1; SPAAT; PRO0684; PRO2209
Gene ID : 5265
mRNA Refseq : NM_001127707
Protein Refseq : NP_001121179
MIM : 107400
UniProt ID : P01009
Chromosome Location : 14q32.1
Function : protease binding;protein binding; serine-type endopeptidase inhibitor activity

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