Recombinant Mouse Serine (or cysteine) Peptidase Inhibitor, Clade E, Member 1
Cat.No. : | Serpine1-5319M |
Product Overview : | Recombinant Mouse Serpine1was expressed in E. coli (PAI-1) + Insect cell culture (tPA). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Serpine1-5319M |
Description : | Mouserecombinant Serpine1complexedto tPA. Mouse sc-tPA is reacted with an excess of mouse Serpine1 stablemutant at physiological pH. The resulting 1:1 molar complex is purified fromthe remaining Serpine1 by affinity chromatography with immobilizedantibodies to mouse tPA. |
Source : | E. coli (PAI-1) +Insect cell culture (tPA) |
Species : | Mouse |
Form : | Frozen liquid in0.4M HEPES + 0.1M NaCl, pH 7.4. |
Purity : | > 95% by SDS-PAGEanalysis. |
Endotoxin Level : | < 0.1 ng/μg ofprotein. |
Concentration : | 1.0 mg/ml |
Storage : | Store at-80°C. Stable at -80°C for 1 year from delivery. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | Serpine1 |
Gene Name : | Serpine1 serine (or cysteine)peptidase inhibitor, clade E, member 1 [ Mus musculus ] |
Synonyms : | Serpine1; serine (orcysteine) peptidase inhibitor, clade E, member 1; PAI1; PAI-1; Planh1;plasminogen activator inhibitor 1; PAI; serpin E1; plasminogen activatorinhibitor, type I; endothelial plasminogen activator inhibitor; nexin,plasminogen activator inhibitor type 1; serine (or cysteine) proteinaseinhibitor, clade E, member 1; Plasminogen activator inhibitor-1 precursor(PAI-1) (Endothelial plasminogen activator inhibitor) (PAI) |
Gene ID : | 18787 |
mRNA Refseq : | NM_008871 |
Protein Refseq : | NP_032897 |
UniProt ID : | P22777 |
Chromosome Location : | 5 G2 |
Pathway : | Adipogenesis; BloodClotting Cascade; Chagas disease (American trypanosomiasis); Complement andCoagulation Cascades; Complement and coagulation cascades; Senescence andAutophagy; TGF Beta Signaling Pathway; p53 signaling pathway |
Function : | protease binding;protein binding; serine-type endopeptidase inhibitor activity |
Products Types
◆ Native Protein | ||
SERPINE1-5514R | Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 | +Inquiry |
SERPINE1-29522TH | Native Human SERPINE1 | +Inquiry |
◆ Lysates | ||
SERPINE1-2383HCL | Recombinant Human SERPINE1 cell lysate | +Inquiry |
SERPINE1-001RCL | Recombinant Rat SERPINE1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0782 | SERPINE1 (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.
Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.
SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.
The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.
In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.
In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.
Customer Reviews (3)
Write a reviewIt has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
When used for experiments, the experimental conditions and results are highly repeatable.
SERPINE1 has good solubility and is easy to operate and purify.
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