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Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1

Cat. No.: SERPINE1-1848H
Product Overview: Recombinantactive human SERPINE1 labeledwith Alexa Fluor 488 by iodoacetamide substitution at the N-terminal cysteine.
Description: SERPINE1 is aprotein that in humans is encoded by the SERPINE1 gene. SERPINE1 is a serineprotease inhibitor (serpin) that functionsas the principal inhibitor of tissue plasminogen activator (tPA) andurokinase (uPA), the activators of plasminogen and hence fibrinolysis (thephysiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1).
Source: E. coli
Species: Human
Molecular Weight: 43 kDa
Form: Frozen liquid in0.05 M Sodium Phosphate Buffer + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
Purity: > 95% by SDS-PAGEanalysis.
Concentration: 2.5 mg/ml
Storage: Store at-80°C. Protect from light. Stable for 3 years from delivery. Avoid repeated freeze-thawcycles.
OfficialSymbol: SERPINE1
Gene Name: SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ]
Synonyms: SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI;PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478;endothelial plasminogen activator inhibitor; serine (or cysteine) proteinaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene ID: 5054
mRNA Refseq: NM_000602
Protein Refseq: NP_000593
MIM: 173360
UniProt ID: P05121
Chromosome Location: 7q21.3-q22
Pathway: Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagasdisease (American trypanosomiasis); Circadian Clock; Complement andCoagulation Cascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Hemostasis; Platelet activation;Platelet degranulation; Regulation of nuclear SMAD2/3 signaling; Response toelevated platelet cytosolic Ca2+; Selenium Pathway; Senescence and Autophagy;TGF Beta Signaling Pathway; p53 signaling pathway
Function: peptidase inhibitoractivity; protease binding; protein binding; contributes_to receptor binding;serine-type endopeptidase inhibitor activity

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