Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
Cat.No. : | SERPINE1-1848H |
Product Overview : | Recombinantactive human SERPINE1 labeledwith Alexa Fluor 488 by iodoacetamide substitution at the N-terminal cysteine. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SERPINE1-1848H |
Description : | SERPINE1 is aprotein that in humans is encoded by the SERPINE1 gene. SERPINE1 is a serineprotease inhibitor (serpin) that functionsas the principal inhibitor of tissue plasminogen activator (tPA) andurokinase (uPA), the activators of plasminogen and hence fibrinolysis (thephysiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). |
Source : | E. coli |
Species : | Human |
Molecular Weight : | 43 kDa |
Form : | Frozen liquid in0.05 M Sodium Phosphate Buffer + 0.1 M NaCl + 1 mM EDTA, pH 6.6. |
Purity : | > 95% by SDS-PAGEanalysis. |
Concentration : | 2.5 mg/ml |
Storage : | Store at-80°C. Protect from light. Stable for 3 years from delivery. Avoid repeated freeze-thawcycles. |
OfficialSymbol : | SERPINE1 |
Gene Name : | SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ] |
Synonyms : | SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI;PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478;endothelial plasminogen activator inhibitor; serine (or cysteine) proteinaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Gene ID : | 5054 |
mRNA Refseq : | NM_000602 |
Protein Refseq : | NP_000593 |
MIM : | 173360 |
UniProt ID : | P05121 |
Chromosome Location : | 7q21.3-q22 |
Pathway : | Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagasdisease (American trypanosomiasis); Circadian Clock; Complement andCoagulation Cascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Hemostasis; Platelet activation;Platelet degranulation; Regulation of nuclear SMAD2/3 signaling; Response toelevated platelet cytosolic Ca2+; Selenium Pathway; Senescence and Autophagy;TGF Beta Signaling Pathway; p53 signaling pathway |
Function : | peptidase inhibitoractivity; protease binding; protein binding; contributes_to receptor binding;serine-type endopeptidase inhibitor activity |
Products Types
◆ Native Protein | ||
SERPINE1-29522TH | Native Human SERPINE1 | +Inquiry |
SERPINE1-5514R | Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 | +Inquiry |
◆ Lysates | ||
SERPINE1-001RCL | Recombinant Rat SERPINE1 cell lysate | +Inquiry |
SERPINE1-2383HCL | Recombinant Human SERPINE1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0782 | SERPINE1 (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (6)
Ask a questionYes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.
Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.
SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.
The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.
In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.
In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.
Customer Reviews (3)
Write a reviewIt has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
When used for experiments, the experimental conditions and results are highly repeatable.
SERPINE1 has good solubility and is easy to operate and purify.
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