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Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1

Cat.No. : SERPINE1-1848H
Product Overview : Recombinantactive human SERPINE1 labeledwith Alexa Fluor 488 by iodoacetamide substitution at the N-terminal cysteine.
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  • Gene Information
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Cat. No. : SERPINE1-1848H
Description : SERPINE1 is aprotein that in humans is encoded by the SERPINE1 gene. SERPINE1 is a serineprotease inhibitor (serpin) that functionsas the principal inhibitor of tissue plasminogen activator (tPA) andurokinase (uPA), the activators of plasminogen and hence fibrinolysis (thephysiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1).
Source : E. coli
Species : Human
Molecular Weight : 43 kDa
Form : Frozen liquid in0.05 M Sodium Phosphate Buffer + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
Purity : > 95% by SDS-PAGEanalysis.
Concentration : 2.5 mg/ml
Storage : Store at-80°C. Protect from light. Stable for 3 years from delivery. Avoid repeated freeze-thawcycles.
OfficialSymbol : SERPINE1
Gene Name : SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ]
Synonyms : SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI;PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478;endothelial plasminogen activator inhibitor; serine (or cysteine) proteinaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene ID : 5054
mRNA Refseq : NM_000602
Protein Refseq : NP_000593
MIM : 173360
UniProt ID : P05121
Chromosome Location : 7q21.3-q22
Pathway : Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagasdisease (American trypanosomiasis); Circadian Clock; Complement andCoagulation Cascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Hemostasis; Platelet activation;Platelet degranulation; Regulation of nuclear SMAD2/3 signaling; Response toelevated platelet cytosolic Ca2+; Selenium Pathway; Senescence and Autophagy;TGF Beta Signaling Pathway; p53 signaling pathway
Function : peptidase inhibitoractivity; protease binding; protein binding; contributes_to receptor binding;serine-type endopeptidase inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there any gene polymorphisms or mutations in SERPINE1, and how do these mutations affect function? 11/13/2022

Yes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.

What are the potential therapeutic applications of SERPINE1 inhibitors or activators? 10/03/2022

Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.

How does SERPINE1 affect apoptosis and repair of nerve cells? 07/17/2022

SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.

What are the new directions or breakthroughs in the study of SERPINE1 and its related molecular mechanisms in future research? 02/18/2022

The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.

Are there other inhibitors or activators in the SERPINE1? 04/03/2021

In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.

How is SERPINE1 related to Alzheimer's disease? 09/07/2020

In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.

Customer Reviews (3)

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Reviews
06/02/2022

    It has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

    07/16/2021

      When used for experiments, the experimental conditions and results are highly repeatable.

      02/28/2021

        SERPINE1 has good solubility and is easy to operate and purify.

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