Recombinant Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1
Cat.No. : | SERPINE1-1866R |
Product Overview : | Thisstable mutant of rabbit SERPINE1 contains a singleconservative mutation (Isoleucine 91 to Leucine) that yields PAI-1 with anenhanced half-life as compared to the wild type. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SERPINE1-1866R |
Description : | SERPINE1 is aprotein that in humans is encoded by the SERPINE1 gene. SERPINE1 is a serineprotease inhibitor (serpin) thatfunctions as the principal inhibitor of tissue plasminogen activator (tPA)and urokinase (uPA), the activators of plasminogen and hence fibrinolysis(the physiological breakdown of blood clots). It is a serine proteaseinhibitor (serpin) protein (SERPINE1). |
Source : | E. coli |
Species : | Rabbit |
Concentration : | 2.5mg/ml |
Form : | Liquidin 0.05 M Sodium Acetate + 0.1M NaCl + 1mM EDTA, pH 5.0. |
Purity : | >95% by SDS-PAGE. |
Molecular Weight : | 43 kDa |
Endotoxin Level : | <0.1 ng/μg of protein. |
Specific Activity : | 80%active by titration with tPA. |
Storage : | Storeat -80°C. Stable for 3years from delivery. For long term use, divide into working aliquots andfreeze at -80°C. Avoid repeatedfreeze-thaw cycles. |
OfficialSymbol : | SERPINE1 |
Gene Name : | SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Oryctolagus cuniculus ] |
Synonyms : | SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; putative plasminogen activator inhibitor-1 |
Gene ID : | 100009588 |
mRNA Refseq : | XM_002722823 |
Protein Refseq : | XP_002722869 |
Products Types
◆ Native Protein | ||
SERPINE1-29522TH | Native Human SERPINE1 | +Inquiry |
SERPINE1-5514R | Native Rabbit Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1 | +Inquiry |
◆ Lysates | ||
SERPINE1-2383HCL | Recombinant Human SERPINE1 cell lysate | +Inquiry |
SERPINE1-001RCL | Recombinant Rat SERPINE1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0782 | SERPINE1 (Human) Chromogenic Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionYes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.
Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.
SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.
The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.
In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.
In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.
Customer Reviews (3)
Write a reviewIt has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
When used for experiments, the experimental conditions and results are highly repeatable.
SERPINE1 has good solubility and is easy to operate and purify.
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