"SERPINF2" Related Products

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Native Human Serpin Peptidase Inhibitor, Clade F (alpha-2 antiplasmin, pigment epithelium derived factor), Member 2

Cat. No.: SERPINF2-5338H
Product Overview: Native human SERPINF2expressed by Human Plasma is a 70.0 kDa protein.
Description: SERPINF2 is a memberof the serpin family of serine protease inhibitors and is a major inhibitorof Plasmin. Consequently, SERPINF2 has a major role in regulating theCoagulation Cascade. Mutations in SERPINF2 result in Alpha-2-AntiplasminDeficiency, a rare coagulation disorder characterized by unrestrainedfibrinolytic activity and severe hemorrhagic diathesis. Individuals with thiscondition may receive therapeutic SERPINF2 prior to surgery to preventpostoperative hemorrhaging.
Source: Human Plasma
Species: Human
Form: Lyophilized from0.02 M Bis-Tris + 0.2 M NaCl, pH 6.4.
Molecular Weight: 70.0 kDa
Concentration: 1.0 mg/ml
Purity: > 95% by SDS-PAGE.
Specific Activity: 19.9IU/mg
Reconstitution: Centrifugevial prior to opening. Reconstitute with sterile distilled waterto originalvolume(0.559 mL).
Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: SERPINF2
Gene Name: SERPINF2 serpin peptidaseinhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor),member 2 [ Homo sapiens ]
Synonyms: SERPINF2; serpinpeptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derivedfactor), member 2; AAP; API; PLI; A2AP; ALPHA-2-PI; alpha-2-antiplasmin; serpinF2; alpha-2-AP; OTTHUMP00000115656; OTTHUMP00000197008; OTTHUMP00000197009; alpha-2-plasmininhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2antiplasmin, pigment epithelium derived factor), member 2
Gene ID: 5345
mRNA Refseq: NM_000934
Protein Refseq: NP_000925
MIM: 613168
UniProt ID: P08697
Chromosome Location: 17p13
Pathway: Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Hemostasis; Platelet activation; Platelet degranulation; Response to elevatedplatelet cytosolic Ca2+
Function: endopeptidaseinhibitor activity; protease binding; protein binding; serine-typeendopeptidase inhibitor activity

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