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Native Human Serpin Peptidase Inhibitor, Clade F (alpha-2 antiplasmin, pigment epithelium derived factor), Member 2

Cat.No. : SERPINF2-5338H
Product Overview : Native human SERPINF2expressed by Human Plasma is a 70.0 kDa protein.
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Cat. No. : SERPINF2-5338H
Description : SERPINF2 is a memberof the serpin family of serine protease inhibitors and is a major inhibitorof Plasmin. Consequently, SERPINF2 has a major role in regulating theCoagulation Cascade. Mutations in SERPINF2 result in Alpha-2-AntiplasminDeficiency, a rare coagulation disorder characterized by unrestrainedfibrinolytic activity and severe hemorrhagic diathesis. Individuals with thiscondition may receive therapeutic SERPINF2 prior to surgery to preventpostoperative hemorrhaging.
Source : Human Plasma
Species : Human
Form : Lyophilized from0.02 M Bis-Tris + 0.2 M NaCl, pH 6.4.
Molecular Weight : 70.0 kDa
Concentration : 1.0 mg/ml
Purity : > 95% by SDS-PAGE.
Specific Activity : 19.9IU/mg
Reconstitution : Centrifugevial prior to opening. Reconstitute with sterile distilled waterto originalvolume(0.559 mL).
Storage : Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : SERPINF2
Gene Name : SERPINF2 serpin peptidaseinhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor),member 2 [ Homo sapiens ]
Synonyms : SERPINF2; serpinpeptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derivedfactor), member 2; AAP; API; PLI; A2AP; ALPHA-2-PI; alpha-2-antiplasmin; serpinF2; alpha-2-AP; OTTHUMP00000115656; OTTHUMP00000197008; OTTHUMP00000197009; alpha-2-plasmininhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2antiplasmin, pigment epithelium derived factor), member 2
Gene ID : 5345
mRNA Refseq : NM_000934
Protein Refseq : NP_000925
MIM : 613168
UniProt ID : P08697
Chromosome Location : 17p13
Pathway : Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Hemostasis; Platelet activation; Platelet degranulation; Response to elevatedplatelet cytosolic Ca2+
Function : endopeptidaseinhibitor activity; protease binding; protein binding; serine-typeendopeptidase inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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