Native Human Serpin Peptidase Inhibitor, Clade F (alpha-2 antiplasmin, pigment epithelium derived factor), Member 2

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Native Human Serpin Peptidase Inhibitor, Clade F (alpha-2 antiplasmin, pigment epithelium derived factor), Member 2

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Cat. No. : SERPINF2-5338H
Product Overview : Native human SERPINF2expressed by Human Plasma is a 70.0 kDa protein.
Description : SERPINF2 is a memberof the serpin family of serine protease inhibitors and is a major inhibitorof Plasmin. Consequently, SERPINF2 has a major role in regulating theCoagulation Cascade. Mutations in SERPINF2 result in Alpha-2-AntiplasminDeficiency, a rare coagulation disorder characterized by unrestrainedfibrinolytic activity and severe hemorrhagic diathesis. Individuals with thiscondition may receive therapeutic SERPINF2 prior to surgery to preventpostoperative hemorrhaging.
Source : Human Plasma
Species : Human
Form : Lyophilized from0.02 M Bis-Tris + 0.2 M NaCl, pH 6.4.
Molecular Weight : 70.0 kDa
Concentration : 1.0 mg/ml
Purity : > 95% by SDS-PAGE.
Specific Activity : 19.9IU/mg
Reconstitution : Centrifugevial prior to opening. Reconstitute with sterile distilled waterto originalvolume(0.559 mL).
Storage : Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : SERPINF2
Identifiers :

Gene Name : SERPINF2 serpin peptidaseinhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor),member 2 [ Homo sapiens ]
Synonyms : SERPINF2; serpinpeptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derivedfactor), member 2; AAP; API; PLI; A2AP; ALPHA-2-PI; alpha-2-antiplasmin; serpinF2; alpha-2-AP; OTTHUMP00000115656; OTTHUMP00000197008; OTTHUMP00000197009; alpha-2-plasmininhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2antiplasmin, pigment epithelium derived factor), member 2
Gene ID : 5345
mRNA Refseq : NM_000934
Protein Refseq : NP_000925
MIM : 613168
UniProt ID : P08697
Chromosome Location : 17p13
Pathway : Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Hemostasis; Platelet activation; Platelet degranulation; Response to elevatedplatelet cytosolic Ca2+
Function : endopeptidaseinhibitor activity; protease binding; protein binding; serine-typeendopeptidase inhibitor activity

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