Native Human Transferring TF-5341H

Native Human Transferring


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Native Human Transferring

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Cat. No. : TF-5341H
Product Overview : Native human TFexpressed by Human Plasma is a 76.5 kDa protein.
Description : Transferrin(TF) is a glycoprotein thought to have been created as a result of an ancient geneduplication event that led to generation of homologous C- and N-terminaldomainseachof which binds one ion of Ferric Iron. Therefore, each Human TF molecule hastheabilityto carry two Iron ions in the Ferric form (Fe3+). The function of TF is totransport Iron fromthe intestine, reticuloendothelial system, and liver parenchymal cells to all proliferatingcells in the body. TF may also have a physiologic role as Granulocyte/Pollen-BindingProtein (GPBP) involved in the removal of certain organic matterand allergens from serum. Apo-Transferrin designates the form of the molecule withoutIron bound. Like TF, APO-TF has a physiological role in the transportationanddistributionof Iron among the body organs. It is also an important transport factor used indefined culture media.
Source : Human Plasma
Species : Human
Form : Lyophilized fromAmmonium Bicarbonate pH 7.2.
Molecular Weight : 76.5 kDa
Reconstitution : Centrifugevial prior to opening. Add deionized water to a concentration of10 mg/Ml, aliquotand freeze unused portion.
Purity : > 95% by SDS-PAGE; Purifiedto have < 0.02 mgIron/g TF.
Storage : Store at -70°C. 3years from delivery. Avoid repeated freeze-thaw cycles.
OfficialSymbol : TF
PDBrendering based on 1a8e. :

Gene Name : TF transferrin [ Homo sapiens]
Synonyms : TF; transferring; TFQTL1;PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155;beta-1 metal-binding globulin
Gene ID : 7018
mRNA Refseq : NM_001063
Protein Refseq : NP_001054
MIM : 190000
UniProt ID : P02787
Chromosome Location : 3q22.1
Pathway : EPHB forwardsignaling; HIF-1-alpha transcription factor network; Hemostasis; Iron uptakeand transport; Mineral absorption; Platelet activation; Plateletdegranulation; Response to elevated platelet cytosolic Ca2+; Transferrinendocytosis and recycling; Transmembrane transport of small molecules
Function : ferric iron binding;metal ion binding; protein binding; ubiquitin protein ligase binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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