Native Human Transferring

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Native Human Transferring

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Cat. No. : TF-5341H
Product Overview : Native human TFexpressed by Human Plasma is a 76.5 kDa protein.
Description : Transferrin(TF) is a glycoprotein thought to have been created as a result of an ancient geneduplication event that led to generation of homologous C- and N-terminaldomainseachof which binds one ion of Ferric Iron. Therefore, each Human TF molecule hastheabilityto carry two Iron ions in the Ferric form (Fe3+). The function of TF is totransport Iron fromthe intestine, reticuloendothelial system, and liver parenchymal cells to all proliferatingcells in the body. TF may also have a physiologic role as Granulocyte/Pollen-BindingProtein (GPBP) involved in the removal of certain organic matterand allergens from serum. Apo-Transferrin designates the form of the molecule withoutIron bound. Like TF, APO-TF has a physiological role in the transportationanddistributionof Iron among the body organs. It is also an important transport factor used indefined culture media.
Source : Human Plasma
Species : Human
Form : Lyophilized fromAmmonium Bicarbonate pH 7.2.
Molecular Weight : 76.5 kDa
Reconstitution : Centrifugevial prior to opening. Add deionized water to a concentration of10 mg/Ml, aliquotand freeze unused portion.
Purity : > 95% by SDS-PAGE; Purifiedto have < 0.02 mgIron/g TF.
Storage : Store at -70°C. 3years from delivery. Avoid repeated freeze-thaw cycles.
OfficialSymbol : TF
PDBrendering based on 1a8e. :

Gene Name : TF transferrin [ Homo sapiens]
Synonyms : TF; transferring; TFQTL1;PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155;beta-1 metal-binding globulin
Gene ID : 7018
mRNA Refseq : NM_001063
Protein Refseq : NP_001054
MIM : 190000
UniProt ID : P02787
Chromosome Location : 3q22.1
Pathway : EPHB forwardsignaling; HIF-1-alpha transcription factor network; Hemostasis; Iron uptakeand transport; Mineral absorption; Platelet activation; Plateletdegranulation; Response to elevated platelet cytosolic Ca2+; Transferrinendocytosis and recycling; Transmembrane transport of small molecules
Function : ferric iron binding;metal ion binding; protein binding; ubiquitin protein ligase binding

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