Native Human Transferring

• Cat.No.: TF-5341H
• Product Overview: Native human TFexpressed by Human Plasma is a 76.5 kDa protein.

Specification

• Cat. No.: TF-5341H
• Description: Transferrin(TF) is a glycoprotein thought to have been created as a result of an ancient geneduplication event that led to generation of homologous C- and N-terminaldomainseachof which binds one ion of Ferric Iron. Therefore, each Human TF molecule hastheabilityto carry two Iron ions in the Ferric form (Fe3+). The function of TF is totransport Iron fromthe intestine, reticuloendothelial system, and liver parenchymal cells to all proliferatingcells in the body. TF may also have a physiologic role as Granulocyte/Pollen-BindingProtein (GPBP) involved in the removal of certain organic matterand allergens from serum. Apo-Transferrin designates the form of the molecule withoutIron bound. Like TF, APO-TF has a physiological role in the transportationanddistributionof Iron among the body organs. It is also an important transport factor used indefined culture media.
• Source: Human Plasma
• Species: Human
• Form: Lyophilized fromAmmonium Bicarbonate pH 7.2.
• Molecular Weight: 76.5 kDa
• Reconstitution: Centrifugevial prior to opening. Add deionized water to a concentration of10 mg/Ml, aliquotand freeze unused portion.
• Purity: > 95% by SDS-PAGE; Purifiedto have < 0.02 mgIron/g TF.
• Storage: Store at -70°C. 3years from delivery. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: TF

Gene Information

• Gene Name: TF transferrin [ Homo sapiens]
• Synonyms: TF; transferring; TFQTL1;PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155;beta-1 metal-binding globulin
• Gene ID: 7018
• mRNA Refseq: NM_001063
• Protein Refseq: NP_001054
• MIM: 190000
• UniProt ID: P02787
• Chromosome Location: 3q22.1
• Pathway: EPHB forwardsignaling; HIF-1-alpha transcription factor network; Hemostasis; Iron uptakeand transport; Mineral absorption; Platelet activation; Plateletdegranulation; Response to elevated platelet cytosolic Ca2+; Transferrinendocytosis and recycling; Transmembrane transport of small molecules
• Function: ferric iron binding;metal ion binding; protein binding; ubiquitin protein ligase binding