Native Human Transferring

Cat. No.: TF-5341H
Product Overview: Native human TFexpressed by Human Plasma is a 76.5 kDa protein.
Description: Transferrin(TF) is a glycoprotein thought to have been created as a result of an ancient geneduplication event that led to generation of homologous C- and N-terminaldomainseachof which binds one ion of Ferric Iron. Therefore, each Human TF molecule hastheabilityto carry two Iron ions in the Ferric form (Fe3+). The function of TF is totransport Iron fromthe intestine, reticuloendothelial system, and liver parenchymal cells to all proliferatingcells in the body. TF may also have a physiologic role as Granulocyte/Pollen-BindingProtein (GPBP) involved in the removal of certain organic matterand allergens from serum. Apo-Transferrin designates the form of the molecule withoutIron bound. Like TF, APO-TF has a physiological role in the transportationanddistributionof Iron among the body organs. It is also an important transport factor used indefined culture media.
Source: Human Plasma
Species: Human
Form: Lyophilized fromAmmonium Bicarbonate pH 7.2.
Molecular Weight: 76.5 kDa
Reconstitution: Centrifugevial prior to opening. Add deionized water to a concentration of10 mg/Ml, aliquotand freeze unused portion.
Purity: > 95% by SDS-PAGE; Purifiedto have < 0.02 mgIron/g TF.
Storage: Store at -70°C. 3years from delivery. Avoid repeated freeze-thaw cycles.
OfficialSymbol: TF
Gene Name: TF transferrin [ Homo sapiens]
Synonyms: TF; transferring; TFQTL1;PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155;beta-1 metal-binding globulin
Gene ID: 7018
mRNA Refseq: NM_001063
Protein Refseq: NP_001054
MIM: 190000
UniProt ID: P02787
Chromosome Location: 3q22.1
Pathway: EPHB forwardsignaling; HIF-1-alpha transcription factor network; Hemostasis; Iron uptakeand transport; Mineral absorption; Platelet activation; Plateletdegranulation; Response to elevated platelet cytosolic Ca2+; Transferrinendocytosis and recycling; Transmembrane transport of small molecules
Function: ferric iron binding;metal ion binding; protein binding; ubiquitin protein ligase binding

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