"TP53" Related Products

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Recombinant Human Tumor Protein P53

Cat. No. : TP53-1076H
Description : p53 wild type is His-tagged at the N-terminus. The protein was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, p53 is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenes
Source : Sf9 insect cells.
Form : Liquid. Supplied in 20mM Tris-HCl pH8.0, 20% glycerol, 100mM KCl, 0.2mM EDTA and 1mM DTT.
Activity : 1ng is sufficient for a gel mobility shift assay in a 20μl reaction, 50ng are sufficient for reconstituted transcription assay and 100ng are sufficient for a protein-protein interaction assay.
Application : Recombinant p53 can be used for: (1) Mobility shift assay or for DNase I footprinting in the presence of double stranded DNA contain a consensus p53- binding sequence [5'-PuPuPuC (A/T) (T/A) GPyPyPy-3']. (2) In vitro transcription assa. (3) Rotein-protein interaction assay. (4) Cell growth assay.
Purity : >95% by SDS-PAGE.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months. Store at -80℃. Avoid freeze / thaw cycles.
Gene Name : TP53 tumor protein p53 [ Homo sapiens ]
Synonyms : TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53
Gene ID : 7157
mRNA Refseq : NM_000546
Protein Refseq : NP_000537
MIM : 191170
UniProt ID : P04637
Chromosome Location : 17p13.1
Pathway : Amyotrophic lateral sclerosis (ALS); Apoptosis; Basal cell carcinoma; Bladder cancer; Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; Glioma; Huntington"s disease; MAPK signaling pathway; Melanoma; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway; p53 signaling pathway; Cell Cycle Checkpoints
Function : ATP binding; DNA strand annealing activity; chaperone binding; chromatin binding; copper ion binding; enzyme binding; metal ion binding; promoter binding; protein N-terminus binding; protein heterodimerization activity; transcription factor activity; transcription factor binding; zinc ion binding

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