Cat. No.:	ACVR1B-5295H
Product Overview:	Recombinant human ACVR1Bprotein is catalytic domain (aa 150-505) and N-terminal GST-tagged, expressedin insect cells.
Description:	ACVR1B is a serine/threonine kinase involved insignal transduction and cellular communication; several truncated ACVR1Bisoforms have been reported to be exclusively expressed in human pituitarytumors and mutations of ACVR1B have been observed in pancreaticadenocarcinomas.
Source:	Insect cells
Species:	Human
Form:	Liquid in 50 mMTris-HCl (pH 7.5) + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
Molecular Weight:	68.2 kDa
Purity:	> 85%
Specific Activity:	> 250 nmolphosphate transferred to Casein substrate/min/mg.
Storage:	Stable for 6 monthsat -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol:	ACVR1B

Gene Name:	ACVR1B activin A receptor, type IB[ Homo sapiens ]
Synonyms:	ACVR1B; activin Areceptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor type-1B;OTTHUMP00000237285; OTTHUMP00000237286; OTTHUMP00000237287;OTTHUMP00000237289; OTTHUMP00000241624; activin receptor-like kinase 4; activinA receptor, type II-like kinase 4; serine/threonine-protein kinase receptorR2; EC 2.7.11.30
Gene ID:	91
mRNA Refseq:	NM_004302
Protein Refseq:	NP_004293
MIM:	601300
UniProt ID:	P36896
Chromosome Location:	12q13
Pathway:	Cytokine-cytokinereceptor interaction; Developmental Biology; MAPK signaling pathway;Regulation of Signaling by NODAL; Signaling by NODAL
Function:	ATP binding; SMADbinding; contributes to activin binding; activin receptor activity, type I;contributes to activin-activated receptor activity; contributes to growthfactor binding; metal ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; receptor activity; transforminggrowth factor beta-activated receptor activity; transmembrane receptorprotein serine/threonine kinase activity; ubiquitin protein ligase binding

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