Recombinant Human Activin A Receptor, Type IB, GST-tagged


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Recombinant Human Activin A Receptor, Type IB, GST-tagged

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Cat. No. : ACVR1B-5295H
Product Overview : Recombinant human ACVR1Bprotein is catalytic domain (aa 150-505) and N-terminal GST-tagged, expressedin insect cells.
Description : ACVR1B is a serine/threonine kinase involved insignal transduction and cellular communication; several truncated ACVR1Bisoforms have been reported to be exclusively expressed in human pituitarytumors and mutations of ACVR1B have been observed in pancreaticadenocarcinomas.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris-HCl (pH 7.5) + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
Molecular Weight : 68.2 kDa
Purity : > 85%
Specific Activity : > 250 nmolphosphate transferred to Casein substrate/min/mg.
Storage : Stable for 6 monthsat -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : ACVR1B
PDB rendering basedon 1rw8. :

Gene Name : ACVR1B activin A receptor, type IB[ Homo sapiens ]
Synonyms : ACVR1B; activin Areceptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor type-1B;OTTHUMP00000237285; OTTHUMP00000237286; OTTHUMP00000237287;OTTHUMP00000237289; OTTHUMP00000241624; activin receptor-like kinase 4; activinA receptor, type II-like kinase 4; serine/threonine-protein kinase receptorR2; EC
Gene ID : 91
mRNA Refseq : NM_004302
Protein Refseq : NP_004293
MIM : 601300
UniProt ID : P36896
Chromosome Location : 12q13
Pathway : Cytokine-cytokinereceptor interaction; Developmental Biology; MAPK signaling pathway;Regulation of Signaling by NODAL; Signaling by NODAL
Function : ATP binding; SMADbinding; contributes to activin binding; activin receptor activity, type I;contributes to activin-activated receptor activity; contributes to growthfactor binding; metal ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; receptor activity; transforminggrowth factor beta-activated receptor activity; transmembrane receptorprotein serine/threonine kinase activity; ubiquitin protein ligase binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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