Recombinant Human Activin A Receptor, Type IB, GST-tagged

• Cat.No.: ACVR1B-5295H
• Product Overview: Recombinant human ACVR1Bprotein is catalytic domain (aa 150-505) and N-terminal GST-tagged, expressedin insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 150-505 a.a.
• Description: ACVR1B is a serine/threonine kinase involved insignal transduction and cellular communication; several truncated ACVR1Bisoforms have been reported to be exclusively expressed in human pituitarytumors and mutations of ACVR1B have been observed in pancreaticadenocarcinomas.
• Form: Liquid in 50 mMTris-HCl (pH 7.5) + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
• Molecular Weight: 68.2 kDa
• Purity: > 85%
• Specific Activity: > 250 nmolphosphate transferred to Casein substrate/min/mg.
• Storage: Stable for 6 monthsat -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: ACVR1B

Gene Information

• Gene Name: ACVR1B activin A receptor, type IB[ Homo sapiens ]
• Synonyms: ACVR1B; activin Areceptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor type-1B;OTTHUMP00000237285; OTTHUMP00000237286; OTTHUMP00000237287;OTTHUMP00000237289; OTTHUMP00000241624; activin receptor-like kinase 4; activinA receptor, type II-like kinase 4; serine/threonine-protein kinase receptorR2; EC 2.7.11.30
• Gene ID: 91
• mRNA Refseq: NM_004302
• Protein Refseq: NP_004293
• MIM: 601300
• UniProt ID: P36896
• Chromosome Location: 12q13
• Pathway: Cytokine-cytokinereceptor interaction; Developmental Biology; MAPK signaling pathway;Regulation of Signaling by NODAL; Signaling by NODAL
• Function: ATP binding; SMADbinding; contributes to activin binding; activin receptor activity, type I;contributes to activin-activated receptor activity; contributes to growthfactor binding; metal ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; receptor activity; transforminggrowth factor beta-activated receptor activity; transmembrane receptorprotein serine/threonine kinase activity; ubiquitin protein ligase binding