Cat. No. :	ACVR1B-5295H
Product Overview :	Recombinant human ACVR1Bprotein is catalytic domain (aa 150-505) and N-terminal GST-tagged, expressedin insect cells.
Description :	ACVR1B is a serine/threonine kinase involved insignal transduction and cellular communication; several truncated ACVR1Bisoforms have been reported to be exclusively expressed in human pituitarytumors and mutations of ACVR1B have been observed in pancreaticadenocarcinomas.
Source :	Insect cells
Species :	Human
Form :	Liquid in 50 mMTris-HCl (pH 7.5) + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
Molecular Weight :	68.2 kDa
Purity :	> 85%
Specific Activity :	> 250 nmolphosphate transferred to Casein substrate/min/mg.
Storage :	Stable for 6 monthsat -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol :	ACVR1B

Gene Name :	ACVR1B activin A receptor, type IB[ Homo sapiens ]
Synonyms :	ACVR1B; activin Areceptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor type-1B;OTTHUMP00000237285; OTTHUMP00000237286; OTTHUMP00000237287;OTTHUMP00000237289; OTTHUMP00000241624; activin receptor-like kinase 4; activinA receptor, type II-like kinase 4; serine/threonine-protein kinase receptorR2; EC 2.7.11.30
Gene ID :	91
mRNA Refseq :	NM_004302
Protein Refseq :	NP_004293
MIM :	601300
UniProt ID :	P36896
Chromosome Location :	12q13
Pathway :	Cytokine-cytokinereceptor interaction; Developmental Biology; MAPK signaling pathway;Regulation of Signaling by NODAL; Signaling by NODAL
Function :	ATP binding; SMADbinding; contributes to activin binding; activin receptor activity, type I;contributes to activin-activated receptor activity; contributes to growthfactor binding; metal ion binding; nucleotide binding; protein binding;protein serine/threonine kinase activity; receptor activity; transforminggrowth factor beta-activated receptor activity; transmembrane receptorprotein serine/threonine kinase activity; ubiquitin protein ligase binding

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