Recombinant Human Interleukin 6 (interferon, beta 2), HQ-tagged


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Recombinant Human Interleukin 6 (interferon, beta 2), HQ-tagged

IL6 Related Products

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Cat. No. : IL6-5309H
Product Overview : Recombinant human IL-6is a 20.9 kDa protein containing 184 amino acid residues. Human IL-6 isactive on murine cells but murine IL-6 is inactive on human cells.
Description : IL-6 is amultifunctional cytokine that has an important role in host defense byregulating immune and inflammatory responses. It is expressed by a variety ofnormal and transformed cells including T cells, B cells,monocytes/macrophages, fibroblasts and various tumor cells. IL-6 has diversebiological functions, it stimulates B-cell differentiation and antibodyproduction, synergizes with IL-3 in megakaryocyte development and plateletproduction, induces expression of hepatic acute-phase proteins, and regulatesbone metabolism.
Source : Hordeum vulgare(barley grain)
Species : Human
Form : Sterile filteredthrough a 0.2 um filter. Lyophilized from 50 mM MES pH 6.5, 500 mM NaCl.
Molecular Weight : 23.9 kDa
Purity : Greater than 95% bySDS-PAGE gel analysis. Purified product carries no pyrogenic orpro-inflammatory contaminants, as assayed with monocyte activation test usingHuman 10-plex Cytokine Assay measuring IL-6, TNF-alpha and IL-1 betainduction.
Endotoxin Level : Endotoxin level isless than 0.005ng per ug of product (0.05EU/ug) as measured by turbidimetrickinetic assay.
Biological Activity : Bioactivity isassayed by measuring the dose dependent effect of human IL-6 on proliferationof TF-1 cells. The EDSO for this batch of recombinant human IL-6 is 0.20ng/ml, corresponding to 5.0 x 106 U/mg specific activity. Optimalconcentration should be determined for specific applications and cell lines.
Reconstitution : Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration not less than 100 ug/ml. Aftercomplete solubilization of the protein, it can be further diluted to otheraqueous solutions.
Storage : Store lyophilizedprotein at -20°C to -80°C. Reconstituted protein is stable for 1 week at2-4°C. For long term storage, aliquot and store at -20°C to -80°C with acarrier protein (0.1%HSA or BSA) as a stabilizer. Please note that theaddition of any carrier protein into this product may produce unwantedendotoxin. This depends upon the particular application employed. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : IL6
PDB rendering basedon 1ALU. :

Gene Name : IL6 interleukin 6 (interferon,beta 2) [ Homo sapiens ]
Synonyms : IL6; interleukin 6(interferon, beta 2); HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2;IFN-beta-2; interferon beta-2; interleukin BSF-2; OTTHUMP00000158544; OTTHUMP00000198486;OTTHUMP00000198489; OTTHUMP00000198490; hybridoma growth factor; CTLdifferentiation factor; B cell stimulatory factor-2; B-cell stimulatoryfactor 2; B-cell differentiation factor
Gene ID : 3569
mRNA Refseq : NM_000600
Protein Refseq : NP_000591
MIM : 147620
UniProt ID : P05231
Chromosome Location : 7p21-p15
Pathway : ATF-2 transcriptionfactor network; Adipogenesis; African trypanosomiasis; Amoebiasis; AndrogenReceptor Signaling Pathway; Cytokine Signaling in Immune system; Cytokinesand Inflammatory Response; Cytosolic DNA-sensing pathway; Graft-versus-hostdisease; HTLV-I infection; Hematopoietic cell lineage; Herpes simplexinfection; IL-6 Signaling Pathway; Immune System; Influenza A
Function : cytokine activity;growth factor activity; interleukin-6 receptor binding; contributes_tointerleukin-6 receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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