Native Human Alpha-1-Microglobulin/Bikunin Precursor
Cat.No. : | AMBP-5312H |
Product Overview : | Native human AMBP wasexpressed in Human Urine. |
- Specification
- Gene Information
- Related Products
Cat. No. : | AMBP-5312H |
Description : | AMBP, also known asprotein HC (for Heterogeneous Charge), is a low molecular weight proteincomponent of plasma first discovered in pathological human urine. AMBP is amember of the lipocalin superfamily. Evidence suggests that Human AMBPfunctions in the regulation of the immune system. |
Form : | Lyophilized in 0.02MAmmonium Bicarbonate. |
Source : | Human Urine |
Purity : | > 98% asdetermined by SDS-PAGE |
Reconstitution : | Reconstitute in0.05M PBS pH 7.0+0.15M NaCl. |
Storage : | Lyophilized powderis stable for 1 year at 2-4 oC. Afterreconstitution store in working aliquots at -20 oC. Avoidrepeated freeze-thaw cycles. |
Gene Name : | AMBPalpha-1-microglobulin/bikunin precursor [ Homo sapiens ] |
Official Symbol : | AMBP |
Synonyms : | AMBP; alpha-1-microglobulin/bikuninprecursor; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL;ITILC; Bikunin; Uristatin; Protein HC; Trypstatin; Uronic-acid-rich protein;Growth-inhibiting protein 19; Inter-alpha-trypsin inhibitor light chain;Complex-forming glycoprotein heterogeneous in charge; OTTHUMP00000021967; OTTHUMP00000063975 |
Gene ID : | 259 |
mRNA Refseq : | NM_001633 |
Protein Refseq : | NP_001624 |
MIM : | 176870 |
UniProt ID : | P02760 |
Chromosome Location : | 9q32-q33 |
Function : | IgA binding; calcium channelinhibitor activity; calcium oxalate binding; heme binding; peptidaseinhibitor activity; transporter activity; serine-type endopeptidase inhibitoractivity; protein homodimerization activity |
Products Types
◆ Recombinant Protein | ||
AMBP-331H | Recombinant Human AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-302R | Recombinant Rat AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
AMBP-128H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
AMBP-127H | Recombinant Human AMBP Protein, His-tagged | +Inquiry |
Ambp-590M | Recombinant Mouse Ambp Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
AMBP-27H | Native Human AMBP | +Inquiry |
◆ Lysates | ||
AMBP-001HCL | Recombinant Human AMBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionAMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.
AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.
AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.
AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.
Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.
AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.
AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.
AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.
AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.
The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.
Customer Reviews (3)
Write a reviewCompatibility with various protein modification detection methods.
Enhanced data reproducibility in protein quantification.
Comprehensive profiling of protein expression patterns.
Ask a Question for All AMBP Products
Required fields are marked with *
My Review for All AMBP Products
Required fields are marked with *
Inquiry Basket