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Native Human Cathepsin B

Cat.No. : CTSB-5328H
Product Overview : Native Human CTSB was expressed in Human Liver.
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  • Gene Information
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Cat. No. : CTSB-5328H
Description : CTSB, a cysteineproteinase, is located in lysosomes and is involved in tissue degradation andrestructuring. Specifically, CTSB is believed to be involved in theintracellular digestion of extracellular proteins taken up by endocytosis.
Form : Frozenliquid in a buffer of 0.05 M Sodium Acetate + 1 mM EDTA, pH 5.0.
Molecular Weight : 27.5 kDa
Purity : > 95% by SDS PAGE
Source : Human Liver
Storage : Productis stable at -80°C for 3 years.
OfficialSymbol : CTSB
Pathways : Antigen processing and presentation;Lysosome
Gene Name : CTSBcathepsin B [ Homo sapiens ]
Synonyms : CTSB; cathepsin B; APPS; CPSB; cathepsin B1; APP secretase; cycteinprotease; OTTHUMP00000116009; OTTHUMP00000229510; OTTHUMP00000229511; OTTHUMP00000229512;OTTHUMP00000229514; OTTHUMP00000229515; OTTHUMP00000229516; Amyloid precursorprotein secretase; EC 3.4.22.1; Cathepsin B; Cathepsin B1
Gene ID : 1508
mRNA Refseq : NM_001908
Protein Refseq : NP_001899
MIM : 116810
UniProt ID : P07858
Chromosome Location : 8p22
Function : cysteine-typeendopeptidase activity; kininogen binding; peptidase activity; proteinbinding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CTSB affect extracellular matrix remodeling in conditions like osteoarthritis? 01/28/2022

CTSB affects extracellular matrix remodeling, relevant in joint diseases like osteoarthritis.

What role does CTSB play in the pathology of neurodegenerative diseases, such as Alzheimer's? 03/29/2020

CTSB is implicated in neurodegenerative diseases, potentially contributing to protein aggregation and neuronal damage.

How do alterations in CTSB expression or activity affect tissue repair and fibrosis? 04/26/2019

Variations in CTSB expression impact tissue repair processes and the development of fibrosis in various organs.

What are the mechanisms by which CTSB modulates apoptosis and cell survival? 09/26/2018

CTSB regulates apoptosis and cell survival, influencing cell fate decisions under stress or damage.

How does CTSB influence the tumor microenvironment and cancer progression? 08/16/2018

CTSB can influence cancer progression by modulating the tumor microenvironment and facilitating tumor cell invasion.

How does CTSB (Cathepsin B) contribute to protein degradation and lysosomal function? 04/01/2018

CTSB is involved in lysosomal protein degradation, essential for cellular waste disposal and recycling.

What is the impact of CTSB in inflammatory responses and immune cell activation? 01/04/2018

CTSB plays a role in inflammation, impacting immune cell function and inflammatory responses.

Customer Reviews (3)

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Reviews
08/08/2021

    Exceptional protein engineering services, our trusted research partner.

    07/13/2021

      Reliable protein crystallography, key for our structural biology research.

      11/15/2018

        Swift protein quantification, improves data reliability in our work.

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