"F2" Related Products

Native Human Coagulation Factor II (thrombin)

Cat. No. : F2-5285H
Product Overview : Native Human F2 was expressedin human plasma.
Description : F2is proteolytically cleaved to form thrombin in the first step of thecoagulation cascade which ultimately results in the stemming of blood loss.F2 also plays a role in maintaining vascular integrity during development andpostnatal life. Mutations in F2 lead to various forms of thrombosis anddysprothrombinemia.
Source : Human plasma
Form : Liquidin 0.1 M NaH2PO4, pH 6.5.
Concentration : 5.0mg/ml
Molecular Weight : 34.3 kDa
Specific Activity : Determinedusing a fibrinogen clotting assay.
Storage : Store in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
Pathways : Angiopoietinreceptor Tie2-mediated signaling; Blood Clotting Cascade; Cell surfaceinteractions at the vascular wall; Class A/1(Rhodopsin-like receptors); CommonPathway; Complement and Coaqulation Cascades; Diabetes pathways; FOXA2 andFOXA3 transcription factor networks; Extrinsic Pathway; Formation of FibrinClot (Clotting Cascade); Hemostasis; Intrinsic Pathway; Regulation of actincytoskeleton; Selenium Pathway; Signal Transduction
Thestructure of human thrombin in complex with the inhibitor hirudin. :

Gene Name : F2 coagulation factor II (thrombin) [ Homosapiens ]
Official Symbol : F2
Synonyms : F2; coagulation factor II (thrombin); PT; prothrombin; serineprotease; OTTHUMP00000197117; OTTHUMP00000197118; OTTHUMP00000233661;prothrombin B-chain; EC; EC 3.4.21; Prothrombin; Coagulation factorII; Activation peptide fragment 1; Activation peptide fragment 2; Thrombinlight chain; Thrombin heavy chain
Gene ID : 2147
mRNA Refseq : NM_000506
Protein Refseq : NP_000497
MIM : 176930
UniProt ID : P00734
Chromosome Location : 11p11
Function : peptidaseactivity;protein binding; serine-type endopeptidase activity; heparin binding;calcium ion binding; growth factor activity; receptor binding; contributes toreceptor binging; thrombospondin receptor activity

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