||Native Human F2 was expressedin human plasma.
||F2is proteolytically cleaved to form thrombin in the first step of thecoagulation cascade which ultimately results in the stemming of blood loss.F2 also plays a role in maintaining vascular integrity during development andpostnatal life. Mutations in F2 lead to various forms of thrombosis anddysprothrombinemia.
||Liquidin 0.1 M NaH2PO4, pH 6.5.
||Determinedusing a fibrinogen clotting assay.
||Store in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
||Angiopoietinreceptor Tie2-mediated signaling; Blood Clotting Cascade; Cell surfaceinteractions at the vascular wall; Class A/1(Rhodopsin-like receptors); CommonPathway; Complement and Coaqulation Cascades; Diabetes pathways; FOXA2 andFOXA3 transcription factor networks; Extrinsic Pathway; Formation of FibrinClot (Clotting Cascade); Hemostasis; Intrinsic Pathway; Regulation of actincytoskeleton; Selenium Pathway; Signal Transduction