"F2" Related Products

Native Human Coagulation Factor II (thrombin)

Cat. No.: F2-5285H
Product Overview: Native Human F2 was expressedin human plasma.
Description: F2is proteolytically cleaved to form thrombin in the first step of thecoagulation cascade which ultimately results in the stemming of blood loss.F2 also plays a role in maintaining vascular integrity during development andpostnatal life. Mutations in F2 lead to various forms of thrombosis anddysprothrombinemia.
Source: Human plasma
Form: Liquidin 0.1 M NaH2PO4, pH 6.5.
Concentration: 5.0mg/ml
Molecular Weight: 34.3 kDa
Specific Activity: Determinedusing a fibrinogen clotting assay.
Storage: Store in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
Pathways: Angiopoietinreceptor Tie2-mediated signaling; Blood Clotting Cascade; Cell surfaceinteractions at the vascular wall; Class A/1(Rhodopsin-like receptors); CommonPathway; Complement and Coaqulation Cascades; Diabetes pathways; FOXA2 andFOXA3 transcription factor networks; Extrinsic Pathway; Formation of FibrinClot (Clotting Cascade); Hemostasis; Intrinsic Pathway; Regulation of actincytoskeleton; Selenium Pathway; Signal Transduction
Gene Name: F2 coagulation factor II (thrombin) [ Homosapiens ]
Official Symbol: F2
Synonyms: F2; coagulation factor II (thrombin); PT; prothrombin; serineprotease; OTTHUMP00000197117; OTTHUMP00000197118; OTTHUMP00000233661;prothrombin B-chain; EC 3.4.21.5; EC 3.4.21; Prothrombin; Coagulation factorII; Activation peptide fragment 1; Activation peptide fragment 2; Thrombinlight chain; Thrombin heavy chain
Gene ID: 2147
mRNA Refseq: NM_000506
Protein Refseq: NP_000497
MIM: 176930
UniProt ID: P00734
Chromosome Location: 11p11
Function: peptidaseactivity;protein binding; serine-type endopeptidase activity; heparin binding;calcium ion binding; growth factor activity; receptor binding; contributes toreceptor binging; thrombospondin receptor activity

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