Native Human Coagulation Factor IX

• Cat.No.: F9-671H
• Product Overview: NativeHuman F9 is prepared from fresh frozen plasma by a combination ofconventional procedures and immunoaffinity chromatography.

Specification

• Cat. No.: F9-671H
• Description: Human F9, activated by either the Contact or Tissue FactorPathway, is esponsible for the activation of Factor X to Xa.
• Source: Human Plasma
• Form: Frozenliquid in 0.02 M Tris-HCl Buffer + 0.1 M NaCl + 0.001 M Benzamidine, pH 7.4.
• BiologicalActivity: Activity isdetermined via clotting assay.
• Endotoxin Level: < 0.1 ng/ug ofprotein.
• Concentration: 5.0 mg/ml
• Molecular Weight: 56 kDa
• Storage: Store at -80°C. Stable for 3 years fromdelivery. Avoid repeated freeze-thaw cycles.
• Pathways: Blood Clotting Cascade; Complement andCoaqulation Cascades; Extrinsic Pathway; Formation of Fibrin Clot (ClottingCascade); Gamma-carboxylation of protein precursors; Gamma-carboxylation,transport, and amino-terminal cleavage of proteins; Hemostasis; IntrinsicPathway; Metabolism of proteins; Post-translational protein modification;Removal of aminoterminal propeptides from gamma-carboxylation proteins

Gene Information

• Gene Name: F9 coagulation factor IX [ Homo sapiens]
• Official Symbol: F9
• Synonyms: F9; coagulation factor IX;FIX;P19; PTC; HEMB; MGC129641; MGC129642; F9p22; factor9; factor IX F9; serine protease; Christmas factor; OTTHUMP00000024154;plasma thromboplastic component; EC 3.4.21.22; EC 3.4.21; Coagulation factorIX; Plasma thromboplastic component; Coagulation factor IX light chain; Coagulationfactor IX heavy chain; Factor IX; hemophilia B
• Gene ID: 2158
• mRNA Refseq: NM_000133
• Protein Refseq: NP_000124
• MIM: 300746
• UniProt ID: P00740
• Chromosome Location: Xq27.1-q27.2
• Function: peptidase activity; calciumion binding; serine-typeendopeptidase activity

Reviews

04/15/2021

The short half-life makes this product very safe.

10/10/2020

This protein has a wide range of applications and can be used in a variety of experiments.

03/27/2019

The method of use is simple, which reduces the experimental time and improves the efficiency.

Q&As

What is the function of F9 protein?

The F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.

How do genetic mutations in the F9 protein affect its function?

Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.

Do F9 protein mutations cause other diseases or affect other physiological processes?

F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.

What diseases can F9 gene mutations cause?

Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.

How is the activity of F9 protein determined?

The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).

What is the structure of F9 protein?

F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.