Recombinant Human Annexin A1, His-tagged ANXA1-5257H

Recombinant Human Annexin A1, His-tagged

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Recombinant Human Annexin A1, His-tagged

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Cat. No. : ANXA1-5257H
Product Overview : Recombinanthuman ANXA1 was expressed in E.coli with an N-terminal Histag.
Description : AnnexinI (ANXA1), otherwise known as Lipocortin 1, is a calcium-dependentphospholipid-binding protein and member of the annexin family, preferentiallyexpressed on the cytosolic face of the plasma membrane, which acts as aninhibitor of phospholipase A2, and may exhibit anti-inflammatory activity.Increased expression of the ANXA1 gene in hairy cell leukaemia, can be usedin immunohistochemistry as a highly-sensitive diagnostic marker.
Form : Purified recombinantprotein-liquid.
Application : ELISA; West Blotting
Preparation : Purified recombinant6x His-tagged ANXA1 expressed in E.coli.
Buffer Solution : 20mM, Tris-HCl 0.5MNaCl, 100mM Imidazole, 1mM Beta-mercaptoethanol, pH8.0.
Molecular Weight : 41.4 kD (368 aminoacid residues with tag).
Concentration : 0.5mg/ml
Storage : Store at -70oC.Storage in frost-free freezers is not recommended. This product should bestored undiluted. Avoid repeated freezing and thawing as this may denaturethe antibody. Should this product contain a precipitate we recommendmicrocentrifugation before use.
Pathways : Class A/1(Rhodopsin-like receptors); Formyl peptide receptors bind formyl peptides andmany other ligands; G alpha (i) signalling events; G alpha (q) signallingevents; GPCR downstream signaling; GPCR ligand binding; Peptideligand-binding receptors; Prostaglandin Synthesis and Regulation; Signalingby GPCR
PDB rendering based on 1ain. :

Gene Name : ANXA1 annexin A1 [ Homosapiens ]
Official Symbol : ANXA1
Synonyms : ANXA1;annexin A1; ANX1;LPC1; annexin A1; p35; annexin-1; calpactin-2; calpactin II; lipocortin I;chromobindin-9; OTTHUMP00000021474; OTTHUMP00000021475; annexin I (lipocortinI); phospholipase A2 inhibitory protein
Gene ID : 301
mRNA Refseq : NM_000700
Protein Refseq : NP_000691
MIM : 151690
UniProt ID : P04083
Chromosome Location : 9q21.13
Function : calcium ion binding;calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity;phospholipase inhibitor activity; phospholipid binding; protein binding;protein binding; protein homodimerization activity; receptor binding;single-stranded DNA binding; structural molecule activity; single-strandedRNA binding

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