"TNFRSF1B" Related Products


Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1B

Cat. No.: TNFRSF1B-5270H
Product Overview: Recombinanthuman TNFRSF1B was expressed in E.coli.
Description: Thesoluble form of human TNFRSF1B, otherwise known as sTNF receptor type II(sTNFRII), is a member of the tumour necrosis factor receptor (TNFR)superfamily, produced by proteolytic cleavage of the membrane form by themetalloprotease TACE. TNFRSF1B plays a key role in regulating theinflammatory response, acting as a receptor for both tumour necrosis factoralpha (TNF-alpha) and TNF-beta, and is also involved in programmed cell deathand anti-viral activity. sTNFRII acts as an inhibitor of TNF-alpha inducedresponses, by acting as a decoy receptor.
Form: Purifiedrecombinant protein-lyophilised
Application: ELISA; WestBlotting; Functional Assays
Preparation: Purified recombinantTNFRSF1B expressed in E.coli.
Buffer Solution: Phosphate bufferedsaline.
Molecular Weight: 18.9 kD (174 aminoacid residues).
Purity: >98% by SDS PAGEand HPLC analysis
Endotoxin Level: <1EU/ug
Activity: Determined by itsinhibitory effect of the TNFRSF1B mediatedcytotoxicity in murine L-929 cells. The ED50 for this effect in the presenceof 0.25 ng/ml of recombinant human TNFRSF1B is 0.125 µg/ml.
Concentration: 0.1mg/ml afterreconstitution.
Storage: Prior toreconstitution store at +4oC. After reconstitution store at -20oC.Storage in frost-free freezers is not recommended. This product should bestored undiluted. Avoid repeated freezing and thawing as this may denaturethe antibody. Should this product contain a precipitate we recommendmicrocentrifugation before use.
Pathways: Adipocytokinesignaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis;Cytokine-cytokine receptor interaction; IL-3 Signaling Pathway; InflammatoryResponse Pathway; TNF receptor signaling pathway; TNF-alpha/NF-kB SignalingPathway
Gene Name: TNFRSF1B tumor necrosis factorreceptor superfamily, member 1B [ Homo sapiens ]
Official Symbol: TNFRSF1B
Synonyms: TNFRSF1B;tumor necrosis factor receptor superfamily, member 1B; p75;TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II;tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75TNF receptor; OTTHUMP00000001784; p80 TNF-alpha receptor; soluble TNFR1Bvariant 1; tumor necrosis factor receptor 2; tumor necrosis factor betareceptor; tumor necrosis factor receptor type II; tumor necrosis factorbinding protein 2
Gene ID: 7133
mRNA Refseq: NM_001066
Protein Refseq: NP_001057
MIM: 191191
UniProt ID: P20333
Chromosome Location: 1p36.22
Function: protein binding;receptor activity; tumor necrosis factor receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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