"RDH12" Related Products

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Recombinant Human Retinol Dehydrogenase 12 (all-trans/9-cis/11-cis), His-tagged

Cat. No.: RDH12-1371H
Product Overview: Recombinanthuman RDH12protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.
Description: RDH12 belongs to theshort-chain dehydrogenases /reductases (SDR) family. RDH12 is expressed,mostly in eye, kidney, brain, skeletal muscle and stomach. It is anNADPH-dependent retinal reductase whose highest activity is toward 9-cis andall-trans-retinol. RDH12 also plays a role in the metabolism of short-chainaldehydes but does not exhibit steroid dehydrogenase activity.
Form: Liquid. In 20 mMTris-HCl buffer (pH 8.0) containing 2 mM DTT, 40% glycerol, 0.2M NaCl.
Molecular Weight: 33.5 kDa(303 aa), confirmed by MALDI-TOF.
Purity: > 90%by SDS-PAGE
Concentration: 0.25mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMGKVVV ITGANTGIGK ETARELASRG ARVYIACRDVLKGESAASEI RVDTKNSQVL VRKLDLSDTK SIRAFAEGFLAEEKQLHILI NNAGVMMCPY SKTADGFETH LGVNHLGHFL LTYLLLERLK VSAPARVVNV SSVAHHIGKIPFHDLQSEKR YSRGFAYCHS KLANVLFTRE LAKRLQGTGV TTYAVHPGVV RSELVRHSSL LCLLWRLFSPFVKTAREGAQ TSLHCALAEG LEPLSGKYFS DCKRTWVSPRARNNKTAERL WNVSCELLGI RWE
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Metabolicpathways; Retinol metabolism; Visual signal transduction; Vitamin A andcarotenoid metabolism
Gene Name: RDH12 retinol dehydrogenase 12(all-trans/9-cis/11-cis) [ Homo sapiens ]
Official Symbol: RDH12
Synonyms: RDH12; retinoldehydrogenase 12 (all-trans/9-cis/11-cis); LCA3; LCA13; SDR7C2;FLJ30273; retinoldehydrogenase 12; all-trans and 9-cis retinol dehydrogenase; retinoldehydrogenase 12, all-trans and 9-cis; short chain dehydrogenase/reductasefamily 7C, member 2
Gene ID: 145226
mRNA Refseq: NM_152443
Protein Refseq: NP_689656
MIM: 608830
UniProt ID: Q96NR8
Chromosome Location: 14q24.1
Function: binding;oxidoreductase activity; retinol dehydrogenase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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