| Cat. No. : |
PCK1-1372H |
| Description : |
PCK1 is a maincontrol point for the regulation of gluconeogenesis. PCK1 plays an importantrole in this process by stimulating hepatic glucose production. Theexpression of PCK1 can be regulated by insulin, glucocorticoids, glucagon,cAMP, and diet. Modulation of the signals governing PCK1 levels presents apotential therapeutic approach to the treatment of Insulin resistance andconsequently obesity. |
| Form : |
Liquid. In 20 mMTris-HCl buffer (pH 8.0) containing 1 mM DTT, 10% glycerol, 0.1M NaCl. |
| Molecular Weight : |
71.7 kDa(646 aa) |
| Purity : |
> 90%by SDS-PAGE |
| Concentration : |
0.5 mg/ml(determined by Bradford assay) |
| Sequences of aminoacids : |
MGSSHHHHHHSSGLVPRGSH MGSHMPPQLQ NGLNLSAKVV QGSLDSLPQA VREFLENNAE LCQPDHIHICDGSEEENGRL LGQMEEEGIL RRLKKYDNCW LALTDPRDVA RIESKTVIVTQEQRDTVPIP KTGLSQLGRW MSEEDFEKAF NARFPGCMKG RTMYVIPFSM GPLGSPLSKI GIELTDSPYVVASMRIMTRM GTPVLEALGD GEFVKCLHSV GCPLPLQKPL VNNWPCNPEL TLIAHLPDRR EIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHML VLGITNPEGE KKYLAAAFPS ACGKTNLAMM NPSLPGWKVE CVGDDIAWMK FDAQGHLRAINPENGFFGVA PGTSVKTNPN AIKTIQKNTI FTNVAETSDG GVYWEGIDEP LASGVTITSW KNKEWSSEDGEPCAHPNSRF CTPASQCPII DAAWESPEGV PIEGIIFGGRRPAGVPLVYE ALSWQHGVFV GAAMRSEATA AAEHKGKIIM HDPFAMRPFF GYNFGKYLAH WLSMAQHPAAKLPKIFHVNW FRKDKEGKFL WPGFGENSRV LEWMFNRIDG KASTKLTPIG YIPKEDALNL KGLGHINMMELFSISKEFWE KEVEDIEKYL EDQVNADLPC EIEREILALK QRISQM |
| Storage : |
Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| Pathways : |
Adipocytokine signalingpathway; Adipogenesis;Citrate cycle (TCA cycle); Diabetes pathways; FOXA2 and FOXA3 transcription factor networks;Gluconeogenesis; Glucose metabolism; Glycolysis/Gluconeogenesis; Insulinsignaling pathway; Metabolic pathways; PPAR signaling pathway; Proximaltubule bicarbonate reclamation; Pyruvate metabolism; TranscriptionalRegulation of White Adipocyte Differentiation |
