"CA8" Related Products

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Recombinant Human Carbonic Anhydrase VIII, His-tagged

Cat. No.: CA8-1388H
Product Overview: Recombinant humanCA8 protein fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.
Description: CA8 wasinitially named CA-related protein because of sequence similarity to otherknown carbonic anhydrase genes. However, this protein lacks carbonicanhydrase activity (i.e., the reversible hydration of carbon dioxide). Itcontinues to carry a carbonic anhydrase designation based on clear sequenceidentity to other members of the carbonic anhydrase gene family. Defects inCA8 are the cause of cerebellar ataxia mental retardation and dysequilibriumsyndrome type 3 (CMARQ3).
Form: Liquid. 20mM Tris-HClbuffer (pH8.0) containing 20% glycerol, 1mM DTT.
Molecular Weight: 35.5 kDa(314aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appearhigher).
Purity: > 90%by SDS - PAGE
Concentration: 1 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMADLSF IEDTVAFPEK EEDEEEEEEG VEWGYEEGVE WGLVFPDANGEYQSPINLNS REARYDPSLL DVRLSPNYVV CRDCEVTNDG HTIQVILKSK SVLSGGPLPQ GHEFELYEVRFHWGRENQRG SEHTVNFKAF PMELHLIHWN STLFGSIDEA VGKPHGIAII ALFVQIGKEH VGLKAVTEILQDIQYKGKSK TIPCFNPNTL LPDPLLRDYW VYEGSLTIPP CSEGVTWILF RYPLTISQLQ IEEFRRLRTHVKGAELVEGC DGILGDNFRP TQPLSDRVIR AAFQ
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: CA8 carbonic anhydrase VIII [ Homosapiens ]
Official Symbol: CA8
Synonyms: CA8; carbonic anhydrase VIII; CALS; CARP;CAMRQ3; CA-VIII; MGC99509; MGC120502; carbonic anhydrase-related protein;CA-related protein; OTTHUMP00000229370; carbonate dehydratase; carbonicanhydrase-like sequence; EC 4.2.1.1
Gene ID: 767
mRNA Refseq: NM_004056
Protein Refseq: NP_004047
MIM: 114815
UniProt ID: P35219
Chromosome Location: 8q11-q12
Pathway: Nitrogen metabolism
Function: carbonate dehydratase activity; metal ionbinding; metal ion binding

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